帕洛诺司琼防治乳腺癌化疗相关性恶心呕吐的临床对照研究  

A Clinical Study of Palonosetron in Prevention of Chemotherapy-related Nausea and Vomiting in Patients with Breast Cancer

作　　者：屈淑贤[1] 郑振东[1] 刘兆喆[1] 张淼[1] 刘良[2] 张冠中[1] 韩雅玲[3] 谢晓冬[1] 

机构地区：[1]沈阳军区总医院肿瘤科,沈阳110840 [2]贵阳医学院第三附属医院,贵阳550000 [3]沈阳军区总医院心血管内科,沈阳110840

出　　处：《解放军医药杂志》2014年第3期27-30,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：科技部十二五重大新药创制平台子课题(2012ZX09303016-002);2012年辽宁省科技攻关计划课题(2012225019)

摘　　要：目的 观察帕洛诺司琼防治乳腺癌化疗相关性恶心呕吐的疗效及安全性.方法 选择2010年1月-2013年6月沈阳军区总医院收治的乳腺癌77例,其中帕洛诺司琼组（A组）38例和托烷司琼组（B组）39例.两组患者均采用含表柔比星方案化疗,分别观察两组化疗后0~5 d内出现恶心、呕吐及食欲不振等消化道反应和便秘、头晕等不良反应.结果化疗后0~24 h两组恶心、呕吐及食欲不振控制率差异均无统计学意义（P＞0.05）,化疗后2~5 d A组对恶心、呕吐控制率明显优于B组（P＜0.05）,食欲不振控制率无差异（P＞0.05）.两组不良反应较轻,无明显差异（P＞0.05）.结论 在乳腺癌化疗中,帕洛诺司琼防治表柔比星引起迟发性恶心呕吐疗效显著,安全性高.Objective To observe the curative effect and safety of Palonosetron in prevention of chemotherapy- related nausea and vomiting in patients with breast cancer. Methods A total of 77 inpatients with breast cancer during January 2010 and June 2013 were randomly divided into Palonosetron group （group A, n = 38） and Tropisetron group （group B, n = 39）. All the patients underwent Epirubicin-containing chemotherapy. The episodes of loss of appetite, nausea and vomiting, and adverse effects such as constipation and dizziness in the two groups within 0-5 d after the chem- otherapy were observed. Results The control rates for loss of appetite, nausea and vomiting in the two groups within 0 - 24 h after chemotherapy showed no statistical differences （ P 〉 0.05 ）. The control rates for nausea and vomiting in group A within 2 - 5 d after chemotherapy were significantly better than those in group B （P 〈 0. 05）, but the difference in control rate for loss of appetite was not statistically significant （P 〉 0.05）. No serious adverse effect was observed in the two groups （P 〉 O. 05）. Conclusion Palonosetron has significant efficacy and high safety in prevention of chemo- therapy-related tardive nausea and vomiting in Epirubicin-containing chemotherapy for breast cancer.

关 键 词：帕洛诺司琼 乳腺肿瘤 化学疗法 辅助 药物毒性 

分 类 号：R737.9[医药卫生—肿瘤]