腹壁侵袭性纤维瘤病1例报告并文献复习  

Aggressive fibromatosis of abdominal wall:a case report and review of literature

作　　者：姚宗浠[1] 刘玉林[1] 葛建明[1] 

机构地区：[1]苏州市吴中人民医院,江苏苏州215128

出　　处：《基层医学论坛》2014年第1期10-12,共3页The Medical Forum

摘　　要：目的探讨侵袭性纤维瘤病的临床、病理、影像学特征及治疗方法。方法报告1例腹壁侵袭性纤维瘤病病例,结合文献探讨该病的临床特点、影像学特征、病理学表现、治疗及预后。结果侵袭性纤维瘤病在临床上较为少见,表现为向周围组织侵袭生长的包块,无包膜,界限不清,活动度差。影像学检查无特异性,难以与其他软组织肿瘤相鉴别。病理学特点:主要由梭形的纤维母细胞和肌纤维母细胞呈束状排列,无明显异型性,核分裂象少。本病易复发,手术治疗应彻底,放疗对肿瘤局部控制及降低复发率有一定作用,同时还有化疗和内分泌等治疗方法。结论侵袭性纤维瘤病是一种局部侵袭性较强的病变,应结合临床表现、CT、MRI及病理学特点诊断本病。治疗关键为首次手术切除范围需广泛,切缘距瘤缘3 cm以上,使切缘完全阴性。放疗可局部控制肿瘤生长及降低复发率。Objective To study on clinical, pathological, radiological feature and treatment of the aggressive fibromatosis （AF）.Methods A case with aggressive fibromatosis was reported,while the discase＆#39;s clinical feature, radiological findings,pathological character,treatment and prognosis were reviewed in the literatures. Results AF is a rare tumor, which was characterized with infiltrative growth, low metastasis rate and high recurrence rate after an incomplete local resection. Iconography is a lock of characteristic, hardly distinguished AF from other soft tissue neoplasms. Microscopically,AF is composed of slender fibroblasts and myofibroblasts within cellagen, a lock of mitotic figures and nuclear atypia. The disease has the polarity of recurrence,en bloc resection and radiotherapy may decrease the local recurrence rate after operation. Chemotherapy, endocrine and targeted therapy may offer a cure. Conclusion Aggressive fibromatosis is a highly invasive local aggressive lesion whose diagnosis results from clinical feature ,CT findings,MRI scans and pathological features. Complete resection is the key for the treatment of AF,and margin from tumor edge should be at least 3 cm above. Meanwhile the radiotherapy may reduce recurrence.

关 键 词：侵袭性纤维瘤病 临床特点 影像学特征 病理学表现 治疗及预后 AGGRESSIVE FIBROMATOSIS (AF) 

分 类 号：R735.5[医药卫生—肿瘤]