以宿主细胞因子为靶点的抗HIV和HCV药物的研究进展  

Research progress of anti-HIV and HCV drugs targeting host cellular factors

作　　者：蒋智[1] 李艳萍[1] 李卓荣[1] 

机构地区：[1]中国医学科学院北京协和医学院医药生物技术研究所,北京100050

出　　处：《中国新药杂志》2014年第6期665-671,730,共8页Chinese Journal of New Drugs

基　　金：国家自然科学基金(81273439)

摘　　要：病毒性疾病的防治已经成为了全球性的公共卫生问题。临床上现有的抗病毒药物多是以病毒蛋白酶为靶点,虽然疗效强,但长期用药后容易产生耐药性,同时新的病毒变种和未知病毒的不断出现,使得具有全新作用机制和广谱特性的抗病毒药物研发迫在眉睫。近年来与病毒复制各个环节有关的宿主细胞因子得到广泛研究,这也为抗病毒药物的研究提供了新的作用靶点。这种抗病毒作用机制不是直接作用于病毒本身,因此就有可能降低耐药的几率,而且还可能具有广谱的抗病毒优势。目前这种新的抗病毒作用方式研究较多的是对HIV-1和HCV药物,所以本文主要对目前研究发现的针对HIV和HCV病毒复制相关的宿主细胞因子为靶点的抗病毒药物研究进展做一简要综述。To prevent and treat viral diseases has become a global health issue. Most of the antiviral drugs in clinic are targeting the viral proteases. These antiviral drugs are highly effective, however, they are easy to get resistance after long time of use. Along with the appearance of new variants of viruses and unknown viruses, the re- search and development of new antiviral drugs with a novel mechanism of action and broad-spectrum biological ac- tivity become necessary. In recent years, host cellular factors involved in viral replication have been extensively studied and provided new targets for antiviral drug development. These new antiviral drugs targeting host cellular factors don＇t directly act on the viruses, so it is possible to reduce the risk of resistance, and may have the advan- tage of broad-spectrum. Currently, this new therapeutic strategy has been mostly used to develop anti-HIV and HCV drugs. Hence,this review will make a brief overview of the research progress of anti-HIV and HCV drugs tar- geting host cellular factors involved in viral replication.

关 键 词：宿主细胞因子 抗病毒 小分子化合物 

分 类 号：R978.7[医药卫生—药品]