稳定同位素示踪法测定青春前期儿童铁吸收率  

Evaluation on the iron absorption of prepubertal children using stable isotopic tracer

作　　者：张宇[1] 黄振武[1] 朴建华[1] 杨艳华[1] 李卫东[1] 杨晓光[1] 

机构地区：[1]中国疾病预防控制中心营养与食品安全所卫生部微量元素营养重点实验室,北京100050

出　　处：《卫生研究》2014年第2期173-176,192,共5页Journal of Hygiene Research

摘　　要：目的利用稳定同位素示踪技术评价青春前期儿童铁吸收率。方法利用人工富集57Fe标记并制备为57FeSO4口服剂,在常规膳食模式下,早、晚餐前经口给予57名受试者,共5天。收集规定时间内受试者全部粪便,前处理后分别经原子吸收分光光度计(AAS)和多接受等离子质谱仪(MC-ICP-MS)测定铁的含量和丰度,以评价青春前期儿童铁的吸收率情况。结果男、女性儿童铁表观吸收率分别为(26.71±2.94)%和(29.76±2.20)%,校正回收率分别为(27.45±2.83)%和(31.01±2.48)%,男性均显著低于女性儿童(P<0.05)。结论空腹口服稳定同位素示踪剂条件下,青春期儿童铁吸收率均较高,但男性吸收率略低于女性。Objective To investigate the iron absorption of prepubertal children using stable isotopic tracer. Methods 57 subjects were orally given 57FESO4, in conventional diet mode, before breakfast and supper and totally for 5 days. All the fecal during the specified time were collected, pre-conducted and determined by AAS and MC-ICP-MS to evaluation the iron absorption of prepubertal children. Results The iron absorption rate of male and female were（26.71 ±2.94）% and（29.76 ± 2.20）%, and the correction absorption rate of iron were（27.45 ±2.83）% and（31.01± 2.48）%, absorption of female were higher than that of male（P 〈 0.05）. Conclusion In the condition of fasting oral SI, there is a high iron absorption rate of prepubertal children, and absorption rate of female is higher.

关 键 词：稳定同位素示踪技术 青春前期 儿童 铁 吸收率 

分 类 号：R153.2[医药卫生—营养与食品卫生学] Q581[医药卫生—公共卫生与预防医学]