p27^(kip1)在胃癌中的表达及与临床病理分期和预后的关系  

Expression of p27^( kip1) in gastric carcinoma and its relation to clinicopathologic stage and prognosis

作　　者：王福生 蒋丹斌 宋怀宇[2] 荆梦杰[2] 苏媛 张廷国[2] 

机构地区：[1]江苏省盐城第三人民医院病理科,盐城224001 [2]山东医科大学附属医院病理科,济南250012

出　　处：《临床与实验病理学杂志》2000年第6期487-488,共2页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的 :探讨 p2 7kip1在胃癌中的表达状况及其预后价值。方法 :应用免疫组化技术 (S P法 )检测了 p2 7kip1在 6 7例胃癌中的表达。结果 :p2 7kip1在胃癌中的阳性表达率为 5 0 7% ,表达呈异质性。p2 7kip1的表达与胃癌的浸润深度 (P <0 0 5 )、淋巴结转移 (P <0 0 0 5 )、分化程度 (P <0 0 5 )及临床病理分期 (P <0 0 0 5 )显著相关 ,而与肿瘤大小、部位无关。结论 :p2 7kip1在胃癌中低表达反映了其恶性进展 。Purpose To discuss the relationship between the expression of p27 kip1 and clinicopathologic parameters and prognosis in gastric carcinoma(GC). Method Sixty seven cases of GC were studied by immunohistochemical technique. Results The positive rate of p27 kip1 expression in GC was 50 7%. Expression of p27 kip1 was heterogenous in GC. Reduced expression of p27 kip1 was significantly related to depth of tumor invasinon, lymph node metastasis, advanced stage and poor differentiation, but had no relation with the tumor size and site. Conclusion These data suggest that reduction of p27 kip1 protein may reflect the progression and high grade malignancy of GC and may be a useful indicator for prognosis.

关 键 词：胃肿瘤 P27^KIP1蛋白 免疫组织化学 病理分期 预后 

分 类 号：R735.2[医药卫生—肿瘤] R730.23[医药卫生—临床医学]