APP转基因小鼠脑中NO与细胞凋亡的研究  

STUDY OF NO AND IN-SITU APOPTOS IN APP TRANSGENIC MICE'S BRAIN

作　　者：秦川[1] 常洋[1] 朱华[1] 

机构地区：[1]北京市中国医学科学院中国协和医科大学实验动物研究所,100021

出　　处：《中国煤炭工业医学杂志》2000年第9期952-953,共2页Chinese Journal of Coal Industry Medicine

基　　金：国家科技部特别资助项目

摘　　要：目的　利用已建立的 APP转基因动物模型 ,探讨 NO与细胞凋亡机制。方法　 NO测定试剂盒和原位凋亡检测试剂盒。结果　转基因小鼠脑中 NO与对照组无显著性差异 ;原位细胞凋亡检查也未发现转基因组与对照组有显著性差异。结论 Aβ的存在可能使细胞处于一种易于凋亡的状态。Objective To inquire into the principles governing NO and in-situ apoptosis by using the APP transgenic animal models. Methods NO detection kit and colorimetric apoptosis detection system were used. Results No significant differences of NO in the transgenic mice's brain and in-situ apoptosis were found when compared with those of the control group. Conclusion The existence of Aβin the Aβpatients may make the neural cells more subject to apoptosis.

关 键 词：APP转基因 脑 小鼠 一氧化氮 老年性痴呆 细胞凋亡 

分 类 号：R749.160.2[医药卫生—神经病学与精神病学]