^(14)C-UBT检测具有上消化道症状幽门螺杆菌感染及家庭聚集性的分析  

Helicobacter pylori infection in patients with upper gastrointestinal symptoms and its family clustering

作　　者：谭晓林[1] 陈明[1] 陈昂[1] 谢彩虹[1] 赵超[1] 陈冬妹[1] 肖文[1] 尹泉[1] 

机构地区：[1]南方医科大学附属中山市博爱医院消化内科,528403

出　　处：《现代消化及介入诊疗》2014年第1期21-24,共4页Modern Interventional Diagnosis and Treatment in Gastroenterology

摘　　要：目的探讨具有上消化道症状病人幽门螺杆菌(Helicobacter pylori,H.pylori)感染状况及家庭聚集性。方法对具有上消化道症状而来我院消化科门诊就诊的病人8 750人,进行14C-尿素呼气试验(14C-urea breath test,14C-UBT)检测H.pylori感染,以及对上述病人进行宣教,动员其家庭成员自愿参加该检测项目,其中资料完整的有840个家庭,共2 905人,确定是否存在H.pylori感染,且问卷登记其家庭环境因素如家庭收入和教育状况等。结果 8 570例具有上消化道症状病人中H.pylori总感染率为61.29%,不同年龄组H.pylori感染率不同(χ2=224.672,P<0.001),且有典型随年龄增长而上升的趋势,但性别间差异无统计学意义(χ2=0.346,P=0.556)。通过二项分布拟合优度检验探讨H.pylori感染的家庭聚集性,H.pylori感染在家庭内的分布不符合二项分布[χ2=22.05,χ2(0.05,3)=7.81,P<0.05不符合二项分布],在理论分布上发现H.pylori感染有家庭聚集性分布趋势,夫妻之间H.pylori感染率情况一致(P=0.494,P>0.05),夫妻H.pylori感染的符合率为56.90%。双亲感染家庭儿童的H.pylori感染率为51%高于双亲未感染家庭儿童的H.pylori感染率为29%(χ2=27.102,P<0.001)。环境因素良好家庭儿童感染的比例(32%)明显低于环境因素一般(49%)及环境因素较差(56%)的两种家庭(χ2=33.543,P<0.001)。结论具有上消化道症状的门诊病人H.pylori感染率较高,性别间差异不明显,家庭成员内H.pylori感染具有聚集性,环境因素与儿童感染H.pylori呈负相关。Objective To explore Helicobacter pylori （H. pylori） infection status and its familial cluster-ing tendency in patients with upper gastrointestinal symptom. Methods Eight thousand seven hundred and fifty outpatients with upper gastrointestinal symptom were enrolled. Patients and their family members under-went a 14C-urea breath test for H. pylori infection status. There were 840 families and 2,905 subjects who par-ticipated in this study. Participants were asked to fill up a questionnaire on life environment factors such as family income and education status, etc. Result The total H. pylori infection rate was 61.29%in 8,750 outpa-tients with upper gastrointestinal symptom. H. pylori infection rate was different in different age groups （χ2=224.672, P＆lt;0.001）. There was no significant difference between male and female （χ2=0.346, P=0.556）. To find out whether H. pylori could infect among family members, binomial distribution test was employed. The results showed that the data did not follow binomial distribution. In theoretical distribution, it was found that H. pylori infection tended to cluster in families. Concurrent infection rate of H. pylori between husband and wife was 56.90%. If parents were H. pylori infected, their children had 51%to be infected by H. pylori, which was much higher than children whose parents did not get H. pylori infection （29%）（χ2=27.102, P＆lt;0.001）. The proportion of children infected by H. pylori in a better environment （32%） was obviously lower than children in normal （49%） and poor environment （56%）. Conclusion Outpatients with upper gastrointestinal symptom has higher incidence of H. pylori infection. Infection among family members may cause family clustering, while the environment is negative correlation on H. pylori infection in children.

关 键 词：幽门螺杆菌 家庭聚集性 14C-尿素呼气试验 

分 类 号：R573[医药卫生—消化系统]