血管正常化与肿瘤免疫治疗  

Vascular Normalization and Cancer Immunotherapy

作　　者：曾俊莉[1,2,3] 袁冬梅[2,3] 刘红兵[2,3] 宋勇[2,3] 

机构地区：[1]南方医科大学研究生院,广州510515 [2]南方医科大学研究生院,南京210002 [3]南京军区南京总院呼吸内科,南京210002

出　　处：《中国肺癌杂志》2014年第3期273-276,共4页Chinese Journal of Lung Cancer

基　　金：国家自然科学基金项目(No.81302032);江苏省临床医学科技专项-重点病种的规范化诊疗研究项目(No.BL2013026)资助~~

摘　　要：免疫治疗是一种颇有前景的抗肿瘤策略。然而,肿瘤中的免疫抑制微环境阻碍了免疫治疗的发展。异常肿瘤血管造成的缺氧,使免疫细胞趋向免疫抑制。并且异常血管通过分泌生长因子及细胞因子,改变免疫细胞的增殖、分化及功能,最终形成免疫抑制的微环境。因此,有效的利用血管生成及肿瘤免疫之间的相互作用,适当的抑制血管形成,促进肿瘤血管正常化,可以改变肿瘤的免疫抑制微环境,成为改善免疫治疗的新策略。现就血管正常化与肿瘤免疫的关系,及二者的联合治疗进行综述。。Immunotherapies, as a promising anticancer therapy stratrg）5 has been paid more and more attentions. However, the abnormal tumor vasculature creates a hypoxic microenvironment that make immune cells toward immune suppression. The immunosuppressive microenvironment seems to impede the development of immunotherapies. Hence, normalization tumor vascular by anti-angiogenesis properly could improve the immunosuppressive miroenvironment. Consequently, the efficacy of the immunotherapies was enhanced. Here, we discuss the effects of vascular normalizing on tumor immunity and propose a potentially strategy to re-engineer the tumor-immune microenvironment and improve cancer immunotherapy.

关 键 词：异常血管形成 免疫抑制微环境 血管正常化 抗肿瘤免疫 

分 类 号：R734.2[医药卫生—肿瘤]