ACLTOP全自动血凝仪纤维蛋白原两种测定方法的应用比较  

Comparison of Application Between Two Different Methods of Fibrinogen Assay by the Automatic Coagulometer of ACL TOP

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作  者:郭忠帅 胡金伟[1] 

机构地区:[1]新疆医科大学第一附属医院医学检验中心,新疆乌鲁木齐830054

出  处:《新疆医学》2014年第1期26-28,共3页Xinjiang Medical Journal

摘  要:目的:比较ACL TOP全自动血凝分析仪上Von Clauss法与PT衍生法(PT-der法)测定纤维蛋白原(FIB)的精密性及其临床应用价值。方法:用Von Clauss法与PT衍生法分别对新鲜混合血浆400例临床样本进行检测。结果:两种方法测定FIB的重复性良好;对临床样本按PT-der法检测结果分阶段做分析,FIB在1.50 g/L^3.50 g/L时,两种方法测定结果相近,差异无统计学意义(P>0.05),FIB<1.50 g/L或FIB>3.50 g/L时,PT-der法结果偏高,差异有统计学意义(P<0.05)。结论在ACL TOP全自动血凝分析仪上,当PT-der法测出的FIB值在1.50 g/L^3.50 g/L时,直接报告结果,当PT-der法测出的FIB<1.50 g/L或FIB值>3.50 g/L时,以Von Clauss法复查的结果发出报告,两者结合应用可确保工作质量,提高实际工作效益。Objective To compare the accuracy and clinical application value of Von Clauss method and Prothrombin time derived fibrinogen determination method(PT-der method) on detecting fibrinogen on ACL TOP automatic coagulation analyzer. Methods: Using Von Clauss method and PT-der method to detect fresh-pooled plasma, 400 clinical samples, respectively. Results: The repetitiveness of the two methods on detecting fibrinogen is good. There was no statistical significance on the difference between the test results of the 20 normal control samples(P 0.05). Dividing into different stages, using PT-der method to analyze the test results of the clinical samples: the level of fibrinogen is between 1.51 and 3.50 g/L, the results of the two methods were close, with no statistical significance(P〈0.05); while the level of fibrinogen is higher than 3.50 g/L and lower than 1.50 g/L, the result of the PT-der method was obviously high, with statistical significance(P〈0.05). Conclusion: On the ACL TOP automatic coagulation analyzer, when the level of fibrinogen detected by PT-der method is between 1.51 and 3.50 g/L, the result is reported directly. While the level of fibrinogen detected by PT-der method is higher than 3.50 g/L and lower than 1.50 g/L, the report is got by using Von Clauss to reexamine it. The combination of the two methods can make sure the quality of the work and improvement of the working efficiency.

关 键 词:纤维蛋白原 Von CLAUSS法 PT-DER法 ACL TOP 

分 类 号:R737.9[医药卫生—肿瘤]

 

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