肺缺血再灌注损伤动物模型的研究进展  

Research Progress in Animal Model of Lung Ischemia-reperfusion Injury

作　　者：张皓[1,2] 齐海[1] 

机构地区：[1]新疆医科大学第二附属医院,新疆乌鲁木齐830063 [2]新疆医科大学

出　　处：《中国医学创新》2014年第6期132-134,共3页Medical Innovation of China

基　　金：新疆维吾尔自治区高校科研计划重点项目(XJEDU2007I23)

摘　　要：缺血再灌注损伤(IRI)是器官移植研究的重点。肺缺血再灌注损伤(LIRI)的发生与白细胞活化分泌促炎因子、活性氧增多、细胞内钙离子浓度升高等有关,因此研究LIRI主要侧重这几个方面。现在各种动物模型(如鼠、兔、犬等)的建立能够很好地模拟这些发生,解决了临床直接研究的难题。文章就这些方面的研究进展作一综述。Ischemia-reperfusion injury（IRI）is a focus in the study of organ transplantation.The occurrence of lung ischemia-reperfusion injury（LIRI）and leukocyte activation increased secretion of pro-inflammatory factor,reactive oxygen species,increased intracellular calcium ion concentration and so on,so the research LIRI focused primarily on these aspects.Now all kinds of animal models（such as the rat,rabbit,dog,etc.）the establishment of well simulate these happen,solved the difficult problem of clinical research directly.The article summarizes the progress on these aspects of the research.

关 键 词：肺 缺血再灌注损伤 动物 模型 

分 类 号：R-332[医药卫生]