高强度聚焦超声在结直肠癌肝转移治疗中的研究现状  

Current status of High-intensity focused ultrasound in the treatment of liver metastases of colorectal cancer research

作　　者：刘贤伟[1] 张建华[1] 杨阳[1] 李鸿江[2] 赵艳东[2] 李春民[1] 周丁华[1] 

机构地区：[1]中国人民解放军第二炮兵总医院肝胆外科,北京100088 [2]山西医科大学研究生学院

出　　处：《肝胆外科杂志》2014年第1期42-45,共4页Journal of Hepatobiliary Surgery

摘　　要：肝脏是结直肠癌最常见也最重要的转移部位,而肝转移是结直肠癌治疗失败最重要的因素之一。手术切除治疗结直肠癌肝转移(CRLM)疗效确切,但手术切除率低且复发率高,化疗、放疗副作用较大,射频消融并发症较多,高温、冷冻等其他治疗效果均不理想。高强度聚焦超声(HIFU)是近年来发展迅速的实体肿瘤局部消融新技术,其不仅具有创伤小、并发症少、恢复快及肿瘤组织坏死确切等优点,还能在有效消融肿瘤病灶的同时保存和提高宿主抗肿瘤免疫能力。近年来,HIFU局部消融在临床治疗中的应用逐步深入,本文拟就其治疗结直肠癌肝转移的机制、现状作一简要综述,并探讨目前存在的问题,展望临床应用前景。Liver is the most common and important metastases sites of colorectal cancer,and liver metastases often leads to the failure of the treatment of colorectal cancer.Surgical treatment of colorectal liver metastases （CRLM） efficacy has certain rote,but has low rescctable rate and high recurrence rate,the side effects of chemotherapy and radiotherapy,high complication of radiofrequency ab lation,hyperthermia,freezing and other treatments are not ideal.With the development of the High Intensity Focused Ultrasound （HIFU） in recent years,the new technologies of local ablation of solid tumors not only has less trauma,fewer complications,faster recovery and definite tumor necrosis,but also can preserve and enhance host antitumor immunity in the effective ablation of tumor lesions.In recent years,With the gradual deepening of HIFU in the clinical treatment,we not only summarize the treatment of cancer liver metastases mechanism and the current situation meanwhile discuss current problems and the prospect of clinical application.

关 键 词：高强度超声聚焦 结直肠癌 肝转移 综合治疗 

分 类 号：R735.37[医药卫生—肿瘤]