抑木汤对肝脾不和型腹泻型肠易激综合征患者结肠黏膜胃肠激素的影响  

Effect of Inhibiting Wood Decoction on Gastrointestinal Hormone in Colonic Mucosa of Patients with Disharmony between Liver and Spleen Type of D- IBS

作　　者：刘铁龙[1] 路越[1] 姚秋园 

机构地区：[1]辽宁中医药大学附属第三医院,辽宁沈阳110003

出　　处：《辽宁中医杂志》2014年第3期495-497,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：辽宁省科学技术计划项目(2011225016)

摘　　要：目的:观察抑木汤对肝脾不和型腹泻型肠易激综合征(D-IBS)患者结肠黏膜胃肠激素的影响。方法:对100例符合标准的肝脾不和型的D-IBS患者使用抑木汤(炒白芍15 g,炒白术15 g,防风15 g,陈皮10 g,黄芪20 g,党参15 g,茯苓20 g,山药20 g,延胡索15 g,滑石粉15 g,补骨脂15 g,炙甘草10 g)。一剂煎3袋,各150 mL。治疗组每天分3次温服,日1剂。治疗3周为1个疗程。间隔1周后,继服第2个疗程。对照组口服思密达5 mg,3次/d,餐后服用。同上法服2个疗程。判定疗效。结果:抑木汤治疗组在治疗后VIP及SP均下降,NPY含量增高,与治疗前比较有统计学差异(P<0.05),VIP及SP第1疗程与第2疗程数值下降不明显,无统计学意义(P>0.05),而NPY含量第1疗程与第2疗程数值下降具有显著性差异(P<0.05);思密达对照组在治疗后VIP及SP均下降,与治疗前比较有统计学差异(P<0.05),第1疗程与第2疗程数值下降不明显,无统计学意义(P>0.05),NPY含量增高,第1疗程与第2疗程数值下降不明显,无统计学意义(P>0.05);治疗组与对照组在治疗后与健康对照组相比有显著性差异(P<0.05)。结论:抑木汤治疗肝脾不和型的D-IBS患者疗效满意。Objective ： To observe the effect of Inhibiting Wood Decoction on gastrointestinal hormone in colonic mucosa of pa- tients with disharmony between liver and spleen type of D - IBS. Method：100 cases of D - IBS patients used Inhibiting Wood De- coction. A dose had 3 bags, each 150 mL. The treatment group took 3 times a day with a dose. 3 weeks was 1 course of treatment. One week interval later,the second treatment course continued. The control group orally took Smecta 5 mg,three times a day after meal. The courses were the same as the treatment group＇s. Determination of curative effect was carried on. Results ：After treatment, VIP and SP in treatment group were decreased and NPY content increased and there was significant difference compared with that before treatment （P 〈 0. 05 ）. VIP and SP numerical first course and second course of treatment were not decreased obviously with no statistical significance （P 〉 0. 05） and the numerical NPY content first course with second course of treatment with the de- crease in significant differences （P 〈 0. 05）. In the control group after treatment,VIP and SP were decreased and there were sig- nificant differences compared with that before treatment （P 〈 0. 05）. The value of a first course with the second course were not decreased obviously with no statistical significance （P 〉 0. 05 ）. The increased NPY content and the value of the first course with the second course were not decreased obviously with no statistical significance （ P 〉 0. 05 ）. The treatment group and the control group before and after treatment were significantly different （P 〈0. 05 ）. Conclusion：The curative effect of Inhibiting Wood Decoc- tion treating patients with D -IBS is satisfactory.

关 键 词：肝脾不和型D—IBS 抑木汤 中医药治疗 

分 类 号：R574.4[医药卫生—消化系统]