不同剂量辛伐他汀治疗脑梗死的临床疗效和药理分析  

The Effect of Different Doses of Simvastatin in the Treatment of Cerebral Infarction and Its Pharmacological Analysis

作　　者：羿凤云 王玮[2] 张红果[2] 吴芳[2] 

机构地区：[1]中国人民武装警察部队北京市总队第三医院药械科,北京100141 [2]中国人民武装警察部队总医院药剂科,北京100039

出　　处：《中国医药导刊》2014年第1期135-136,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨两种剂量辛伐他汀对脑梗死的临床治疗效果,并分析其药理作用。方法:我院在2010年10月至2013年3月期间共接诊脑梗死患者150例,将其随机分成实验组(75例)和对照组(75例),两组均给予常规基础治疗,在此基础上对照组给予辛伐他汀(20毫克/天),实验组(40毫克/天),均在睡前顿服,连续治疗一疗程(12周)。对比分析两组的DNS评分、临床疗效及不良反应等。结果:两组在治疗前DNS评分无明显差异(P>0.05),在治疗后实验组的DNS评分为(9.15±4.33)分显著低于对照组(14.31±3.92)分,两组差异比较有统计学意义(t=7.1170,P<0.01)。实验组治疗有效率为94.67%,显著高于对照组(81.33%),两组差异比较有统计学意义(X2=7.1932,P<0.05)。两组均未出现严重不良反应,且不良反应发生率无明显差异(P>0.05)。结论:在常规治疗的基础上,给予大剂量的辛伐他汀可显著降低神经功能的缺损程度,提高治疗效果,同时不良反应反应发生率无明显提高,因此应在临床中推广应用。Objective：To discuss the efect of two doses of simvastatin on treatment of cerebral infarction, and analyzes its pharmacological. Methods：There were 150 cases with cerebral infarction, randomly divided into experimental group （75 cases） and control group （75 cases）, all were given conventional foundation treatment, then the control group was given simvastatin （20 mg/day）, the experimental group （40 mg/day）, 12 weeks for a course. Compare DNS grading, clinical efficacy and adverse reactions between the two groups.Results：Before treatment, the DNS between the two groups had no difference （P〉0.05）, after treatment, the DNS in experimental group（9.15±4.33） is significantly lower than it in control group （14.31±3.92）（P〈0.01）. The effective rate in experimental group was 94.67%, significantly higher than that of control group （81.33%） （P〈0.05）. No severe adverse reaction occurred in both groups, and the incidence of adverse drug reactions have no obvious difference （P〉0.05）.Conclusion：on the basis of routine treatment, large doses of simvastatin can significantly reduce the degree of nerve function defect, improve the effect of treatment, the incidence of adverse reactions have no obvious increase at the same time, so it should be applied in clinical.

关 键 词：辛伐他汀 脑梗死 不同剂量 疗效 药理 

分 类 号：R743.3[医药卫生—神经病学与精神病学]