D-dimer及PF1+2与晚期恶性肿瘤患者静脉血栓栓塞症的相关性的研究  

The Correlation of D-dimer and PF1+2 in Malignant Patients with Venous Thromboembolism

作　　者：李秀翠[1] 蒋华[1] 姜维美[1] 付梅[1] 杨恒[1] 胡春霞[1] 刘燕文[1] 

机构地区：[1]连云港市第二人民医院,江苏连云港222023

出　　处：《肿瘤学杂志》2014年第3期234-237,共4页Journal of Chinese Oncology

基　　金：连云港市卫生局科研项目(1017)

摘　　要：[目的]探讨血浆D-dimer及PF1+2与晚期恶性肿瘤患者静脉血栓栓塞症(VTE)的相关性。[方法]150例晚期恶性肿瘤患者随机分为2组,其中117例无VTE的患者为非栓塞组,33例发生VTE的患者为栓塞组。所有患者均在化疗前及第2、第4、第6个疗程化疗后第7d至第10d期间检测血浆中D-dimer和PF1+2的含量。[结果]随着化疗的进行患者血浆D-dimer、PF1+2呈上升趋势,且栓塞组高于非栓塞组(P<0.05);恶性肿瘤患者血浆中Ddimer和PF1+2呈显著正相关关系(r=0.53,P<0.05),而D-dimer、PF1+2与患者的年龄、性别、病程、病理分型、临床分期均无相关性(P>0.05);多因素Logistic回归分析结果显示:血浆Ddimer、PF1+2是化疗后VTE发生的独立危险因素,而接受抗凝治疗是化疗后VTE发生的保护因素。[结论]血浆D-dimer、PF1+2对晚期恶性肿瘤患者VTE的发生具有一定的诊断价值,接受化疗的晚期恶性肿瘤患者应采取适当的抗凝治疗预防VTE的发生。[Purpose] To investigate the correlation of D-dimer and PF1 ＋2 with in malignant patients complicated with venous thromboembolism（VTE）. [Methods] One hundred and fifty malignancies were randomly divided into two groups：non-embolization group（117 cases without VTE） and embolization group（33 cases with VTE）. The plasma D-dimer and PF1＋2 were tested in all patients before chemotherapy,and at the seventh day to the tenth day during the second,fourth,sixth course of chemotherapy respectively. [Results]The plasma D-dimer,PF1 ＋2 increased with the progress of chemotherapy,and the embolization group had higher leves than the the non-embolization group（P＆lt;0.05）.The D-dimer and PF1＋2 had a significant positive correlation in malignant patients（r =0.53,P ＆lt;0.05）,while the D-dimer,PF1 ＋2 had no correlation with the patient’s age,gender,duration of disease,pathological type,clinical stage（P＆gt;0.05）.Logistic regression analysis showed that plasma D-dimer,PF1＋2 were the independent risk factors for VTE after chemotherapy,and anticoagulation therapy after chemotherapy was the protective factor for VTE. [Conclusion] Plasma D-dimer,PF1＋2 have diagnostic value for VTE in malignant patients. The advanced cancer patients undergoing chemotherapy treatment should take anticoagulation therapy to prevent the occurrence of VTE.

关 键 词：肿瘤 静脉血栓栓塞症 D-DIMER PF1+2 

分 类 号：R730.43[医药卫生—肿瘤]