子宫肌壁间肌瘤经皮微波消融后中远期疗效观察  

Follow-ups of mid-term and long-term outcomes for uterine intramural myomas after percutaneous microwave ablation therapy

作　　者：郝艳丽[1] 张晶[1] 韩治宇[1] 徐瑞芳[1] 马霞[1] 杨宇[1] 周洪雨[1] 葛海龙[1] 董雪娟[1] 

机构地区：[1]解放军总医院介入超声科,北京100853

出　　处：《中华医学杂志》2014年第9期664-666,共3页National Medical Journal of China

基　　金：军队十二五课题（CWS11J310）;北京市首都特色课题（Z131107002213144）

摘　　要：目的 评价超声引导经皮微波消融（PMAT）治疗症状性子宫肌壁间肌瘤中远期临床疗效.方法 前瞻性研究解放军总医院2008年8月至2012年8月123例超声引导PMAT治疗的症状性子宫肌壁间肌瘤患者临床疗效.比较治疗前、治疗后1、2、3及4年肌瘤体积（FV）,血红蛋白量（HGB）,子宫肌瘤症状及与健康相关生活质量（UFS-QOL）评分.结果 治疗后1年,FV缩小74.5%;贫血患者HGB从（91＆#177;11） g/L上升至（114＆#177;20） g/L;UFS-QOL中子宫肌瘤症状评分（SSS）及与健康相关生活质量评分（HRQL）分别从43＆#177;10、41＆#177;21变化至18＆#177;16、90＆#177;16;治疗后2、3、4年4项参数均维持在治疗后1年时水平无明显变化.结论 超声引导PMAT子宫肌壁间肌瘤可使肌瘤有效缩小甚至完全消失,有效改善患者中远期临床症状,提高生活质量.Objective To evaluate the mid-term and long-term clinical outcomes for symptomatic intramural uterine myoma after ultrasound-guided percutaneous microwave ablation therapy （PMAT）. Methods A total of 123 women with intramural uterine myoma underwent PMAT. Prospective studies were conducted to compare the dominant fibroid volume （FV）, hemoglobin （HGB） and Uterine Fibroid Symptoms and Quality of Life Questionnaire （UFS-QOL） at baseline and 1, 2, 3 and 4 years of follow-up Results Comparing with the baseline, the shrinkage rate of FV at 1 year follow-up was 74.5%. HGB of anemic patients pre-PMAT increased from 91＆#177;11 to 114＆#177;20 g/L. Two parts of UFS-QOL symptoms severity scores （SSS） and health-related quality of life （HRQL） changed from 43＆#177;10 to 18＆#177;16 and 41＆#177;21 to 90＆#177;16 respectively at 1year follow-up. All four items stayed nearly the same at 2, 3 and 4 years post-therapy. Conclusion Ultrasound-guided PMAT of uterine fibroids can effectively ameliorate the mid-term and long-term clinical syndromes and improve quality of life by shrinking fibroids effectively or even disappearing completely.

关 键 词：超声检查 介入性 微波 平滑肌瘤 

分 类 号：R737.33[医药卫生—肿瘤]