老年冠心病患者PCI后hs-CRP和脑钠肽水平改变  

Effect of Interventional Treatment on Brain Natriuretic Peptide and hs-CRP Levels in Patients with Coronary Heart Disease

作　　者：张科[1] 谭红霞[1] 卢建刚[1] 

机构地区：[1]涪陵区中心医院老年科,重庆涪陵408000

出　　处：《贵阳医学院学报》2014年第1期67-69,共3页Journal of Guiyang Medical College

摘　　要：目的:探讨经皮冠状动脉介入治疗(PCI)后老年冠心病患者血清C-反应蛋白(hs-CRP)和脑钠肽(BNP)水平的改变。方法:选取84例接受PCI的老年冠心病患者作为实验组,另外选取同期进行冠状动脉造影(CAG)的老年患者53例作为对照组,采用酶联免疫法(ELISA)检测两组术前及术后血清hs-CRP及BNP的水平变化。结果:术前两组患者的血清hs-CPR水平差异无统计学意义(P>0.05);PCI后1周内实验组患者血清hsCPR水平先升高后下降,术后12 h时水平最高,1周后接近术前浓度。术后1 h、12 h、48 h与术前血清hs-CPR水平相比,差异有统计学意义(P<0.05);而对照组患者的血清hs-CPR水平则比较稳定,术前、术后比较差异无统计学意义(P>0.05)。术前两组患者的血清BNP水平比较无统计学意义(P>0.05);PCI后1周内实验组患者血清BNP水平一直呈下降趋势,术后1 h、12 h、48 h及术后1周与术前血清BNP水平相比均具有统计学意义(P<0.05);而对照组患者术后1周内血清BNP水平虽然也呈下降趋势,但是与术前水平比较均无统计学意义(P>0.05)。结论:PCI后患者血清hs-CRP升高而BNP水平降低,可能与血管局部或全身的炎症反应及治疗后病情得到有效缓解有关。Objective：To investigate the effect of interventional treatment on brain natriuretic peptide and high-sensitivity C-reactive protein （hs-CRP） levels in elderly patients with coronary heart disease.Methods：A total of 84 elderly patients with coronary heart disease received interventional treatment were chosen as the experimental group,while 53 elderly patients underwent coronary angiography （CAG） were selected for control group.Preoperative and intraoperative hs-CRP and serum brain natriuretic peptide levels were detected using enzyme-linked immunosorbent assay （ELISA） test.Results：There was no significant difference between preoperative serum hs-CPR levels of the two groups of patients （P 〉 0.05）.After one week of experimental intervention,serum hs-CPR levels increased and then decreased in 12 h after treatment.Compared with preoperative serum hs-CPR levels,there were significant differences in serum hs-CPR levels in 1 h,12 h,48 h after treatment（P 〈0.05）.While the control group of patients with serum hs-CPR levels were relatively stable before surgery,there was no significant difference （P 〉 0.05）.Within a week,after interventional treatment,experimental group serum BNP levels were in a downward trend,there were significant differences in 1 h,12 h,48 h after treatment,and in one week after treatment,compared with preoperative serum BNP levels （P 〈0.05）.In the control group patients although serum BNP also showed a downward trend in one week after treatment,but there was no significant difference compared with the preoperative levels （P 〉 0.05）.Conclusions：After PCI,serum hs-CRP level elevating may be due to local or systemic inflammatory response,clinical treatment should be taken for inflammatory responses after PCI.Serum BNP levels decrease significantly due to treatment and the disease mitigation.

关 键 词：冠状动脉硬化 心脏病 脑钠肽 C反应蛋白 介入治疗 炎症 

分 类 号：R363.21[医药卫生—病理学] R541.4[医药卫生—基础医学]