血小板膜外周型苯二氮卓受体在初发脑梗死后抑郁中的作用  

Effects of peripheral-type benzodiazepine receptors in platelet membrane on patients with depression after first attack of cerebral infarction

作　　者：陈嫄[1] 陈春富[1] 李聪聪[1] 肖萧[1] 

机构地区：[1]山东大学附属省立医院神经内科,山东济南250021

出　　处：《中国病理生理杂志》2014年第3期543-546,共4页Chinese Journal of Pathophysiology

基　　金：山东省自然科学基金重点项目(No.Z2007C03)

摘　　要：目的:观察卒中后抑郁(PSD)患者血小板膜外周型苯二氮卓受体(PBRs)的变化,探讨PBRs在PSD中的作用。方法:卒中后抑郁组为初发脑梗死后PSD患者43例、脑梗死组为初发脑梗死患者59例、对照组为健康献血者46名。采用Hamilton抑郁量表(HAMD)评定患者抑郁程度。提取外周血血小板膜,应用放射性配基[3H]PK11195结合实验测定PBRs特异结合活性。结果:[3H]PK11195结合活性3组之间有显著差异(P<0.01)。与对照组[(298.2±25.1)pmol/(g protein)]比较,脑梗死组[3H]PK11195结合活性[(1 410.8±41.4)pmol/(g protein)]显著升高(P<0.01)。与脑梗死组比较,PSD组[3H]PK11195结合活性[(361.7±30.6)pmol/g protein]显著降低(P<0.01)。PSD组男性、女性患者之间比较,[3H]PK11195结合活性差异不显著。PSD组[3H]PK11195结合活性与患者病程无显著相关性(r=0.27,P>0.05),与HAMD评分呈显著负相关(r=-0.44,P<0.01)。结论:PSD患者血小板膜PBRs结合活性下降,PBRs影响抑郁程度。AIM： To evaluate the changes of peripheral-type benzodiazepine receptors （PBRs） in platelet membrane in post-stroke depression （PSD） patients and to investigate the effects of PBRs on PSD. METHODS： Forty three patients with PSD, fifty-nine patients with first-ever cerebral infarction and fifty-six healthy volunteers participated in this study. Platelet membrane in venous blood was prepared. Binding assay of the radioactive PBRs antagonist [ 3H ] PK11195 to platelet membrane was performed. RESULTS ： A significant difference of [ 3 H ] PK11195 binding was found among the 3 groups （P 〈0.01 ）. Compared with the healthy volunteers [ （298.2 ± 25.1 ） pmol/（g protein）], a highly significant increase in [ 3 H ] PK11195 binding was observed in platelet membrane in the patients with first attack of cerebral infarction [ （ 1 410.8 ±41. 4） pmol/（ g protein）, P 〈 0.01 ]. Compared with the patients with first attack of cerebral in farction, a significant reduction in [3HI PKll195 binding was detected in platelet membrane in the patients with PSD [ （361.7 ± 30.6） pmol/（ g protein）, P 〈 0.01 ]. In the patients with PSD, no significant difference of [ 3 H ] PK11195 binding was found between men and women （ P 〉 0.05 ）. [ 3 H ] PK11195 binding was related to the score of Hamilton de pression rating scale （ r = - 0.44, P 〈 0.01 ） but not to tpe duration of cerebral infarction （ r = 0.27, P 〉 0.05 ）. CON- CLUSION： PBRs binding activity in platelet membrane decreases in the patients with PSD and affects the degree of de pression.

关 键 词：卒中后抑郁 脑梗死 外周型苯二氮卓受体 血小板 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]