长链非编码RNA多态性与肿瘤相关性的研究  

Association between long non-coding RNA polymorphisms and cancers

作　　者：邓齐文[1] 许晔琼[1] 王书奎[1] 

机构地区：[1]南京医科大学附属南京医院中心实验室,南京医学硕士研究生210006

出　　处：《医学研究生学报》2014年第3期303-306,共4页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81172141)

摘　　要：长链非编码RNAs(long non-coding RNAs,LncRNAs)是一类转录本长度超过200个核苷酸残基(nt)的RNA分子,位于细胞核或细胞质内,大多由RNA聚合酶Ⅱ转录,但不能编码蛋白质。越来越多的证据表明LncRNA基因也发生遗传变异,导致LncRNA基因存在着广泛的基因多态性,而大多数LncRNA基因多态性与肿瘤的发生、转移和预后相关。文中结合国内外最新报道,对LncRNAs多态性与前列腺癌、肝癌、膀胱癌、急性淋巴细胞性白血病及甲状腺肿瘤的相关性研究进展作一综述,旨在为肿瘤的诊断和治疗提供新的思路。Long non-coding RNAs （LncRNAs） , located in the nucleus or cytoplasm, are a class of RNA molecules with length longer than 200 nucleotides lacking the capability of encoding protein and mostly transcribed by RNA Polymerase II. Abundant evidences proved that lots of genetic variants occurred in LncRNA genes, led to wide polymorphisms of LncRNA genes which involved in carcinogenesis, metastasis and prognosis. This review summarized the recent progresses, both in the domestic and overseas, in the association between LncRNA polymorphisms and human cancers including prostatic cancer, liver cancer, bladder cancer, acute lym-phoblastic leukemia and thyroid carcinoma.

关 键 词：长链非编码RNAs 多态性 肿瘤 

分 类 号：R730.231[医药卫生—肿瘤]