乳腺癌术后复发转移间隔与临床病理因素相关性分析  

Correlation analysis between recurrence and metastasis interval and clinical pathologic factors in breast cancer patients

作　　者：刘琪[1,2] 郭晓龙[3] 左文述[1] 郑美珠[1] 王新昭[1,2] 刘岩松[1] 于志勇[1] 

机构地区：[1]山东省肿瘤医院外科二病区山东省乳腺病防治中心,山东济南250117 [2]济南大学·山东省医学科学院医学与生命科学学院,山东济南250000 [3]淄博市妇幼保健院外一科

出　　处：《中华肿瘤防治杂志》2014年第7期522-527,共6页Chinese Journal of Cancer Prevention and Treatment

基　　金：山东省科技发展计划(2011GSF11823)

摘　　要：目的:探讨乳腺癌术后复发转移时间与临床病理及有关生物学因素的相关性,对乳腺癌术后复发转移风险进行评估。方法:收集2007-10-01-20120-10-31山东省肿瘤医院确诊为乳腺癌术后复发转移的195例女性患者临床病理资料,分析其术后复发转移间隔与临床病理特征的相关性。结果:195例乳腺癌患者5年内复发转移166例(85.13%),其中3年内复发转移129例(66.15%);5年以上复发转移29例(14.87%)。术后复发转移间隔与月经状况(P=0.018)、分子分型(P=0.001)、ER(P=0.001)、PR(P=0.014)及HER-2(P=0.014)表达状况有相关性,差异有统计学意义;进一步单因素分析显示,月经状况(P=0.001)、原发灶肿瘤直径(P=0.044)、分子分型(P=0.034)、ER(P=0.027)及HER-2(P=0.020)表达状况与乳腺癌术后复发转移间隔有相关性,差异有统计学意义;多因素分析结果显示,月经状况、原发肿物直径及HER-2表达状况是乳腺癌术后复发转移间隔的独立危险因素。结论:未绝经、原发肿物直径≥2cm及HER-2过表达是乳腺癌术后发生早复发转移的影响因素。OBJECTIVE： To evaluate risk factors of breast tumor recurrence and metastasis interval after surgery. METHODS： To collect the clinical pathological data of 195 patients, which were diagnosed with the post-operation recur rence and metastasis of breast cancer in Shandong Cancer Hospital from October 1 st, 2007 to October 31 st, 2012, and ana-lyze correlation between recurrence interval and clinical pathological status. RESULTS ： Of 195 patients, 166 （85.13% ） pa-tients had recarrence in 5 years,129（66.15%） patients in 3 years,and 29（33. 850/oo） in more than 5 years. The chi-square test result showed that statistically significant difference of recurrence and metastasis interval were in menstrual status （P=0. 018）,molecular subtype （P=0. 001）,expression status of ER （P= 0. 001）,PR （P=0. 014） and HER-2 （P= 0. 014）. The factors related to recurrence and metastasis interval in univariate analysis were as follow： menstrual status （P=0. 001） ,the primary tumor diameter （P = 0. 044）, molecular subtype （P = 0. 034）, expression status of ER （P = 0. 027） and HER-2 （P=0. 020）. Multivariate analysis showed that menstrual status,primary tumor diameter and expres-sion status of HER-2 were independent risk factors for breast cancer recurrence and metastasis interval. CONCLUSIONS： Premenopause status,diameter o{ primary tumor d≥2 cm and positive expression of HER-2 were associated with shorter interval of recurrence and metastasis in breast cancer patients after surgery.

关 键 词：乳腺肿瘤 外科学 乳腺肿瘤 病理学 肿瘤转移 危险因素 

分 类 号：R737.9[医药卫生—肿瘤]