急性脑梗死患者血清脂联素的水平变化及性别差异  

Analysis of changing and gender differences in concentration of serum adiponectin in patients with acute cerebral infarction

作　　者：高金颖[1] 陈忠云[2] 李珊珊[2] 谷洁[1] 韩艳[1] 刘岚[1] 

机构地区：[1]航天中心医院健康管理部,北京100049 [2]航天中心医院神经内科,北京100049

出　　处：《中华临床医师杂志（电子版）》2013年第24期101-104,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的探讨急性脑梗死(ACI)及其亚型的血清脂联素水平变化,并探讨脂联素水平是否存在性别差异。方法采用病例-对照研究,纳入中国汉族ACI患者160例和80例非ACI对照,按TOAST分型对ACI进行分组。应用酶联免疫吸附法(ELISA)测定血清脂联素水平。结果 (1)病例组中血清脂联素水平明显低于对照组[(5.88±1.91)mg/L vs.(7.56±2.19)mg/L],差异有统计学意义(P<0.01);(2)ACI亚型不同,脂联素水平不同,大动脉粥样硬化性卒中(LAA)组水平最低,小动脉闭塞性卒中或腔隙性卒中(SAA)组居中,心源性栓塞(CE)组水平最高[(5.25±1.60)mg/L vs.(6.05±2.07)mg/L vs.(7.17±1.71)mg/L],两两比较,差异均有统计学意义(P<0.05);(3)在对照组中,男性血清脂联素水平显著低于女性血清脂联素水平[(7.01±2.09)mg/L vs.(8.22±2.15)mg/L],差异有统计学意义(P<0.01),在ACI组中,并未发现存在性别差异;(4)多因素Logistic回归分析显示,脂联素是ACI,尤其是LAA、SAA发生的保护因素。结论血清脂联素水平降低可能是ACI的一个危险因素;在ACI组中脂联素水平未发现性别差异;LAA血清脂联素水平较其他ACI亚型低。Objective To investigate the association of the serum levels of adiponectin in patients with acute cerebral infarction and its subtypes and whether there is gender difference in the serum levels of adiponectin. Methods A total of 160 patients with acute cerebral infarction and 80 control subjects were recruited in this case-control study. The serum adiponectin levels were measured by enzyme-linked immunosorbent assay（ELISA）, patients with cerebral infarction were grouped according to TOAST types. Results （1） The serum adiponectin levels in patient group were significantly lower than those in control group, （5.88 ±1.91）mg/L vs. （7.56±2.19）mg/L; （2） The serum adiponectin levels were differed in diverse stroke subtypes, being lowest in large-artery atherosclerosis group, intermediate in small-artery occlusion group, and highest in cardioembolism group, （5.25 ±1.60）mg/L vs. （6.05 ± 2.07）mg/L vs. （7.17± 1.71）mg/L, significantly different were found between multiple comparisons（P〈 0.05）; （3） The serum adiponectin levels of males were significantly lower than those of females （7.01 ±2.09）mg/L vs. （8.22±2.15）mg/L in control group （P〈0.01）, but no significant gender difference was found in the serum levels of adiponectin in acute cerebral infarction group; （4） Multivariate logistic regression analysis showed that adiponectin was the protective factor of acute cerebral infarction, especially for large-artery atherosclerosis and small-artery occlusion. Conclusions Decreased serum levels of adiponectin may be a risk factor for acute cerebral infarction. No significant gender difference was found in the sertun levels of adiponectin in acute cerebral infarction group. The large-artery atherosclerosis group was significantly lower than in the other subtypes of acute cerebral infarction.

关 键 词：脑梗死 脂联素 性别因素 

分 类 号：R743.33[医药卫生—神经病学与精神病学]