Biodegradable polymeric nanoparticles based on amphiphilic principle:construction and application in drug delivery  

作　　者：ZHANG ShiYong WU Yao HE Bin LUO Kui GU ZhongWei 

机构地区：[1]National Engineering Research Center for Biomaterials, Sichuan University

出　　处：《Science China Chemistry》2014年第4期461-475,共15页中国科学（化学英文版）

基　　金：supported by the National Basic Research Program of China(2011CB606206);the National Natural Science Foundation of China(21372170,51133004 and 81361140343);the Recruitment Program ofGlobal Young Experts of China,the Setup Foundation of Sichuan University(YJ201317);the Excellent Young Teachers Program of SichuanUniversity(2082604164235)

摘　　要：The use of nanotechnology in drug-delivery systems(DDS) is attractive for advanced diagnosis and treatment of cancer diseases. Biodegradable polymeric nanoparticles, for example, have promising applications as advanced drug carriers in cancer treatment. In this review, we discuss the development of drug-delivery systems based on an amphiphilic principle mainly conducted by our group for anti-cancer drug delivery. We first briefly address the synthetic chemistry for amphiphilic biodegradable polymers. In the second part, we summarize progress in the application of self-assembled polymer micelles using amphiphilic biodegradable copolymers as anti-tumor drug carriers.The use of nanotechnology in drug-delivery systems （DDS） is attractive for advanced diagnosis and treatment of cancer diseases. Biodegradable polymeric nanoparticles, for example, have promising applications as advanced drug carriers in cancer treatment. In this review, we discuss the development of drug-delivery systems based on an amphiphilic principle mainly con- ducted by our group for anti-cancer drug delivery. We first briefly address the synthetic chemistry for amphiphilic biodegrada- ble polymers. In the second part, we summarize progress in the application of self-assembled polymer micelles using am- phiphilic biodegradable copolymers as anti-tumor drug carriers.

关 键 词：biodegradable polymer miceUe AMPHIPHILICITY drug-delivery system CANCER 

分 类 号：TQ317[化学工程—高聚物工业] TB383.1[一般工业技术—材料科学与工程]