不同化疗方案对乳腺癌近期疗效的影响  

Effect of different chemotherapy schemes on the efficacy of breast cancer

作　　者：梁良[1] 王晓珊[1] 刘迪[1] 

机构地区：[1]四川省人民医院肿瘤科,成都610072

出　　处：《中国肿瘤临床与康复》2014年第3期299-301,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨不同化疗方案治疗乳腺癌的近期疗效及不良反应。方法2013年5月至2013年5月间收治的女性Ⅱ～Ⅲ期乳腺癌患者88例，随机分为对照组和观察组，每组44例。对照组患者采用CEF（环磷酰胺＋表阿霉素＋氟尿嘧啶）方案，观察组患者采用ET（表阿霉素＋紫杉醇）方案，比较两组患者的疗效和不良反应。结果治疗后，观察组患者总有效率（90．9％）明显高于对照组总有效率（70．5％），两组差异有统计学意义（P〈0．05）。两组患者均未出现肝功能损伤及心肌损伤，而恶心呕吐、脱发等不良反应发生率则为100％。观察组患者中有24例出现骨髓抑制，对照组患者中有14例出现骨髓抑制，两组间差异有统计学意义（P〈0．05）。结论在乳腺癌患者的新辅助化疗中，ET化疗方案优于CEF方案，但ET方案引起的不良反应较严重，临床应用时需酌情用量且密切监测患者不良反应发生情况，及时给予适当的缓解治疗。Objective To investigate recent efficacy and adverse reactions of breast cancer chemo- therapy. Methods 88 cases of female patients with breast cancer in II - III stages hoapitalized in our hos- pital from May 2013 to May 2013 were randomly divided into control group and observation group （44 cases in each group respcetively）. The control group received CEF （cyclophosphamide ＋ epirubicin ＋ fluoroura- cil） regimen,and observation group ET （epirubicin and paclitaxel）. Recent efficacy and adverse reactions were compared. Results After treatment, the total efficiency of the observation group （90. 9% ） was signif- icantly higher that of the control group （70. 5% ）, there was significant differences between the two groups （P 〈0. 05）. All patients did not suffered from liver injury and myocardial injury,but adverse reaction rates such as nausea,vomiting and hair loss reached 100%. There were 24 cases of bone marrow suppression in the observation group ,and 14 cases in the control group, there was significant differences between the two groups （P 〈 O. 05）. Conclusions In breast cancer neoadjuvant chemotherapy,ET chemotherapy is superi- or to CEF program,but ET program has more serious adverse reactions, which require close monitoring adverse reactions and appropriate dosage ajustment, and appropriate remission should be timely given accord- ingly.

关 键 词：药物疗法 乳腺肿瘤 疗效 不良反应 

分 类 号：R737.9[医药卫生—肿瘤]