脂联素在甲状腺乳头状癌的表达及其与临床病理特征的关系  

Expression and clinicopathological correlation studies of Adiponectin in papillary thyroid carcinoma

作　　者：仲秀秀[1,2] 崔文[3] 张国安[3] 侯森[4] 王帅[1] 周健[4] 

机构地区：[1]山东省医学科学院,山东济南250022 [2]济南大学山东省医学科学院医学与生命科学学院,济南250062 [3]济宁医学院基础学院,山东济宁272067 [4]济宁医学院司法鉴定中心,济宁272067

出　　处：《济宁医学院学报》2014年第1期24-26,共3页Journal of Jining Medical University

基　　金：山东省自然科学基金(ZR2009CM070);济宁市科技发展计划(2011-31);济宁医学院青年基金(JYQ2011KM006);山东省高等学校科技计划项目(J13LK14);山东省高校优秀科研创新团队计划资助

摘　　要：目的研究脂联素在甲状腺乳头状癌中的表达及其与临床病理特征的关系。方法用免疫组化的方法检测78例乳头状甲状腺癌组织和12例甲状腺腺瘤组织中脂联素的表达情况。结果脂联素在甲状腺乳头状癌中的阳性表达率(94.4%),在甲状腺腺瘤中的阳性表达率(66.74%),两者比较差异有统计学意义(P<0.05)。在78例甲状腺乳头状癌中,72例脂联素表达阳性组与6例脂联素表达阴性组比较,术前体重和肿瘤多发性与脂联素的表达有显著性差异(P<0.05)。结论脂联素的表达与术前体重和肿瘤多发性有关,可能参与肿瘤的发生和发展。Objective This study aimed to investigate the possible association between the expression of adi-ponectin and clinicopathological variables in papillary thyroid cancer.Methods The expression of adiponectin was detected by immunohistochemistry（IHC）in 78 PTC tissuesand 12 thyroid adenoma tissues.Results The rates of positive expression adiponectin were 94.4%（72/78）and 66.74%（4/12）in papillary thyroid carcinoma and thy-roid adenoma tissues.The difference between the two groups was significant（P〈0.05）.In papillary thyroid carci-noma tissues.There was a significant correlation between the expression of adiponectin and preoperative body weight and multicentricity（P〈0.05）.Conclusion The expression of adiponectin is associated with preoperative body weight and multicentricity.Maybe adiponectin participate in propagation and growth of the tumor cells.

关 键 词：甲状腺乳头状癌 脂联素 

分 类 号：R736.1[医药卫生—肿瘤]