子宫肌瘤复发患者FAS和FAS-L的表达水平及其临床意义  

Expression levels and clinical significances of FAS and FAS-L in patients with recurrence of uterine fibroid

作　　者：李冬梅[1] 张立会[2] 石博[3] 闻春艳[4] 

机构地区：[1]长春大学特殊教育学院,吉林长春130022 [2]吉林大学第二医院妇科 [3]吉林大学基础医学院 [4]吉林大学中日联谊医院病理科

出　　处：《中国妇幼保健》2014年第11期1663-1665,共3页Maternal and Child Health Care of China

基　　金：吉林省科技厅科研项目〔20130101178JC〕

摘　　要：目的:探讨子宫肌瘤复发患者FAS和FAS-L的表达水平及其临床意义。方法:随机选择子宫肌瘤剔除术后复发患者,取其首次剔除的肌瘤组织、瘤旁正常子宫平滑肌组织和复发剔除的肌瘤组织、瘤旁正常子宫平滑肌组织的病理存档蜡块各100例。采用免疫组织化学方法检测首次肌瘤组织、瘤旁正常子宫平滑肌组织和复发肌瘤组织、瘤旁正常子宫平滑肌组织中FAS和FAS-L的蛋白表达水平。结果:复发瘤旁正常子宫平滑肌组织中FAS和FAS-L的蛋白表达水平低于首次瘤旁正常子宫平滑肌组织,差异有统计学意义(P<0.05)。与瘤旁正常子宫平滑肌组织比较,首次和复发的肌瘤组织FAS、FAS-L的蛋白表达水平均明显降低,差异有统计学意义(P<0.01);且复发肌瘤组织中FAS和FAS-L的蛋白表达水平明显低于首次肌瘤组织,差异有统计学意义(P<0.01)。结论:FAS和FAS-L参与了子宫肌瘤的复发,与子宫肌瘤的复发有密切的关系。Objective： To explore the expression levels and clinical significances of FAS and FAS - L in patients with recurrence of uterine fibroid. Methods： The patients with recurrence after myomectomy were selected randomly; 100 removed fibroid tissue specimens for the first time, 100 normal tissue specimens adjacent to tumor, 100 removed recurrent fibroid tissue specimens, and 100 normal tissue speci- mens adjacent to recurrent fibroid were obtained; immunohistochemical method was used to detect the expression levels of FAS protein and FAS - L protein in the four groups. Results ： The expression levels of FAS protein and FAS - L protein in 100 normal tissue specimens adjacent to recurrent fibroid were statistically significantly lower than those in 100 normal tissue specimens adjacent to tumor （P 〈 0.05 ） ; the expression levels of FAS protein and FAS - L protein in 100 removed fibroid tissue specimens for the first time and 100 removed recurrent fibroid tissue specimens were statistically significantly lower than those in 100 normal tissue specimens adjacent to tumor and 100 normal tissue specimens adjacent to recurrent fibroid （P 〈 0. 01 ） ; the expression levels of FAS protein and FAS - L protein in 100 removed recurrent fibroid tissue specimens were statistically significantly lower than those in 100 removed fibroid tissue specimens for the first time （P 〈 0. 01 ） . Conclusion ： FAS and FAS - L participate in recurrence of uterine fibroid, which are closely correlated with recurrence of uterine fibroid.

关 键 词：子宫肌瘤 复发 FAS FAS—L 

分 类 号：R737.33[医药卫生—肿瘤]