调控Muller细胞去分化为视网膜前体细胞的信号通路  

The signaling pathways regulating Muller cells to dedifferentiate into the retinal progenitor cells

作　　者：陶醉[1] 李瑶琛[1] 阴正勤[1] 

机构地区：[1]第三军医大学西南眼科医院视觉损伤与再生修复重庆市重点实验室,重庆400038

出　　处：《生命科学》2014年第3期287-294,共8页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金重大国际(地区)合作研究项目(非组织间协议项目)(30910103913);国家自然科学基金面上项目(81271021)

摘　　要：在视网膜中,Muller细胞被视为具有干细胞特性及再生修复能力,刺激内源性干细胞活化增殖并向视网膜前体细胞去分化,或许是治疗视网膜疾病的重要策略之一。然而,在高等哺乳动物视网膜中,Muller细胞自发去分化的能力极为有限。近年来研究发现,某些生长因子、转录因子及细胞外基质能通过一系列信号通路促进视网膜Muller细胞的去分化及再生修复。阐明这些信号通路的调控机制将对利用内源性干细胞治疗视网膜疾病有极大的帮助。In the retina, Muller cells are considered to have stem cell properties and regenerative ability. Stimulating the endogenous stem cells to proliferate and dedifferentiate into retinal progenitor cells may be one of the important strategies for the treatment of retinal diseases. In the retina of higher mammals, however, the spontaneous dedifferentiation ability of Muller cells is very limited. In recent years, studies have found that some growth factors, transcription factors, extracellular matrix can promote the dedifferentiation and regeneration ability of Muller cells through a series of signaling pathways. Ascertaining these regulatory mechanisms of signaling pathways will be a great help to utilize the endogenous stem cells to treat retinal diseases.

关 键 词：MULLER细胞 去分化 视网膜前体细胞 信号通路 

分 类 号：R774[医药卫生—眼科]