婚姻状态对阴茎鳞状细胞癌预后影响的回顾性研究  

The effects of marital status on prognosis of patients with squamous cell carcinoma of the penis

作　　者：顾伟杰[1,2] 朱耀[1,2] 姚旭东[1,2] 张世林[1,2] 戴波[1,2] 张海梁[1,2] 施国海[1,2] 叶定伟[1,2] 

机构地区：[1]复旦大学附属肿瘤医院泌尿外科,上海200032 [2]复旦大学上海医学院肿瘤学系

出　　处：《中国男科学杂志》2014年第2期19-22,25,共5页Chinese Journal of Andrology

摘　　要：目的：探讨婚姻状态与阴茎鳞状细胞癌（SCCP）患者的预后疗效关系。方法利用SEER数据库1988年至2009年诊断为SCCP的病例2681例。Logistic回归分析婚姻状态与肿瘤分期的关系。Cox回归分析婚姻状态与肿瘤特异性死亡（CSM）的关系。结果本次研究对象中，结婚组患者占62.1%，而从未结婚组和分居、离婚和丧偶（SDW）组分别为15.8和22.1%。多因素Logistic回归分析显示婚姻状态可能并不是影响肿瘤分期的因素（P＞0.05）。多因素Cox回归分析发现，相比于婚姻状况良好组，SDW （HR：1.194；P=0.005）组和未结婚组（HR：1.155, P=0.037）的CSM更高。结论婚姻状态可能并不是影响肿瘤分期的独立因素，但是婚姻状况不佳（未结婚和SDW）的病例CSM更高。Objective To investigate the relationship between marital status and prognosis of patients with squamous cell carcinoma of the penis （SCCP）. Methods 2681 SCCP patients between 1988 to 2009 who underwent primary tumor excision （PTE）, registered in Surveillance, Epidemiology, and End Results （SEER） database, were retrospectively analyzed. Logistic regression analysis defined the relationship of marital status and tumor stage. Cox regression analysis determined the relationship between marital status and cancer-specific mortality （CSM）. Results Of all patients, the majority （62.1%） were married. 22.1 and 15.5%patients were separated/divorced/widowed （SDW） and never married men, respectively. Multivariable Logistic models analysis showed that marital status had no effects on tumor stage （P〉0.05）. Multivariable Cox models analysis showed that the never married and SDW men had higher CSM rates （hazard ratio [HR]：1.194, P=0.005, HR：1.155, P=0.037, respectively） than married men. Conclusion Marital status might not be an independent risk factor for tumor stage. However, SDW and never married men had higher CSM rates than married men.

关 键 词：阴茎肿瘤 婚姻状况 SEER规划 

分 类 号：R737.27[医药卫生—肿瘤]