FXR在胃粘膜肠化生及胃癌中的表达及其意义研究  

The Study of Expression and Significance for FXR in the Gastric Mucosal Intestinal Metaplasia and Gastric Cancer

作　　者：苏林娜[1] 刘向强[1] 吕丽芬[1] 聂勇战[1] 时永全[1] 

机构地区：[1]第四军医大学西京消化病医院肿瘤生物学国家重点实验室

出　　处：《现代生物医学进展》2014年第10期1875-1878,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81270445;81370484)

摘　　要：目的:研究FXR在胃炎,胃粘膜肠化生及胃癌组织中的表达,分析其在胃癌发生中的意义。方法:采用免疫组化方法检测FXR在55例胃炎组织,61例胃黏膜肠化生组织及61例胃癌组织中的表达,利用统计学方法 SPSS17.0软件分析其在三种组织中的表达变化,结合文献回顾,分析FXR在胃癌发生中的意义。结果:FXR在胃黏膜肠化生中的表达明显高于胃炎组织(P<0.05),而在胃癌组织中,FXR的表达显著低于胃粘膜肠化生组织(P<0.05)。结论:FXR是一个潜在的胃癌发生生物标记物,其具体机制有待于进一步探索。Objective： To investigate the expression of FXR in gastritis tissues, gastric mucosal intestinal metaplasia tissues and gastric cancer tissues, and analyze the significance of FXR in gastric carcinogenesis. Methods： Immunehistochemistry was performed to detect the FXR expression in gastritis, intestinal metaplasia tissues, and gastric cancer tissues, and the expressional relation between these three groups of tissue were analyzed by SPSS17.0. The significance of FXR in gastric cancer was also analyzed. Results： The expression of FXR in gastric mucosal intestinal metaplasia tissues was significantly higher than that in gastritis tissues （P〈0.05）. However, in the gastric cancer group, the FXR expression was clearly lower than that in gastric mucosal intestinal metaplasia tissues （P〈0.05）. Conclusion： FXR is a potential gastric biomarker, and its machenisms were to be studied in future.

关 键 词：肠化生 FXR 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]