CK7、CK18、CK5/6及P63在不同类型肺癌组织中的表达分析  

Analysis of the expression of CK7, CK18, CK5/6 and P63 in various types of lung cancer tissues

作　　者：朱栋麟[1,2] 沈荣明[1,2] 刘晓强[1,2] 崔建勇[1,2] 杨勇[1,2] 朱一蒙[1,2] 

机构地区：[1]南京医科大学附属苏州医院 [2]苏州市立医院东区胸外科,215000

出　　处：《中国实用医药》2014年第5期1-3,共3页China Practical Medicine

摘　　要：目的探讨CK7、CK18、CK5/6及P63在各类型肺癌组织中的表达情况。方法对104例肺癌手术标本进行免疫组化分析,联合检测CK7、CK18、CK5/6及P63的表达,同时分析它们在不同类型肺癌中的表达情况。结果 CK7在腺癌、腺鳞癌及大细胞癌中的阳性表达率分别为91.07%、85.71%及50.00%,在鳞癌和小细胞癌中无阳性表达。CK18在腺癌、腺鳞癌、小细胞癌及大细胞癌中的阳性表达率分别为96.43%、85.71%、100%及100%,在鳞癌中无阳性表达。CK5/6在鳞癌中的阳性表达率为100%,在腺癌、腺鳞癌、小细胞癌及大细胞癌中无阳性表达。P63在鳞癌和腺鳞癌中的阳性表达率分别为100%及14.29%,在腺癌、小细胞癌及大细胞癌中无阳性表达。结论 CK7及CK18可用于肺腺癌诊断,CK5/6及P63可用于肺鳞癌诊断。同时,CK18还可用于肺小细胞癌及大细胞癌的诊断。Objective To evaluate the expression of CK7, CK18, CK5/6 and P63 in various types of lung cancer. Methods The expression of CK7, CK18, CK5/6 and P63 proteins in 104 specimens of lung cancer were detected by immunohistochemistry. And the expression of CK7, CK18, CK_5/6 and P63 in different types of lung cancer tissues were also analyzed. Resnlts The positive expression of CK7 in adenocarcinoma, adenosquamous carcinoma and large cell carcinoma were 91.07%, 85.71% and 50.00% respectively. And there was no positive expression in squamous cell carcinoma and small cell carcinoma. The positive expression of CK18 in adenocarcinoma, adenosquamous carcinoma, small cell carcinoma and large cell carcinoma were 96.43%, 85.71%, 100 % and 100% respectively. And there was no positive expression in squamous cell carcinoma. The positive expression of CK5/6 in squamous cell carcinoma was 100%. And there was no positive expression in adenocarcinoma, adenosquamous carcinoma, small cell carcinoma and large cell carcinoma. The positive expression of P63 in squamous cell carcinoma and adenosquarnous carcinoma were 100% and 14.29%. There was no positive expression in adenocarcinoma, small cell carcinoma and large cell carcinoma. Conclusion CK7and CK18 can be used in diagnosis of lung adenocarcinoma. CK5/6 and P63 can be used in diagnosis of lung squamous cell carcinoma. Meanwhile, CK18 can be used in the diagnosis of lung small cell carcinoma and large cell carcinoma.

关 键 词：肺癌 免疫组化 CK7 CK18 CK5/6 P63 

分 类 号：R734.2[医药卫生—肿瘤]