IL-10基因C-592A多态与冠心病遗传易感性的相关性  

C-592A polymorphism of IL-10 gene and genetic susceptibility to coronary heart disease

作　　者：左洪鹏[1] 车琳[1] 吴先正[1] 

机构地区：[1]同济大学附属同济医院急诊医学科,上海200065

出　　处：《同济大学学报（医学版）》2014年第1期7-10,共4页Journal of Tongji University(Medical Science)

基　　金：上海市市级医院新兴前沿技术联合攻关项目(SHDC12010117);上海市卫生局科技项目(2008082);上海市重大科技攻关项目(05DZ19505)

摘　　要：目的探讨IL-10基因启动子C-592A多态与冠心病遗传易感性的关系。方法采用TaqMan方法检测212例冠心病患者（冠心病组）与218名健康体检者（对照组）的IL-10C-592A基因型及等位基因分布，以非条件Logistic回归法计算表示相对危险度的比值比（oddratio，OR）及其95％可信区间（confidence intervals，CI）。结果冠心病组IL-10-592A等位基因频率（76．2％）显著高于对照组（68．3％）；A等位基因型的冠心病发病风险较C等位基因型显著增加（OR：1．48，95％CI：1．10-2．00，P=0．010）。两组人群的C．592A基因型分布差异有统计学意义（P=0．042）；AA基因型的冠心病发病风险相比C等位基因携带者（CC、CA基因型）呈显著增加（OR：1．64，95％CI：1．12—2．42，P：0．012）。结论IL-10基因C-592A多态性可增加我国人群的冠心病发病风险，可作为冠心病高危人群的筛选指标。Objective To investigate the association of C-592A polymorphism in promoter region of IL-IO gene with coronary heart disease （CHD）. Methods The IL-10 C-592A genotypes were determined using the Real-Time PCR technology with TaqMan assay in 212 CHD cases and 218 sex, age-matched controls. Unconditional logistic regression model was used to calculate the odds ratio （ORs） for CHD and 95% confidence interval （CI）. Results A significant correlation between CHD and IL-10 C-592A genotypes was found. The frequency of allele A of IL-10 C-592A was 0.762 in CHD cases and 0. 683 in controls, respectively. The allele A had a significantly increased risk for CHD （OR： 1.48, 95% CI： 1.10- 2.00, P = 0.010） as compared to the allele C. When compared with allele C carriers （CA or CC genotypes）, AA homozygote had a 1.64-fold increased risk （95% CI：1.12 - 2.42, P = 0. 012） of CHD. Conclusion The IL-10 C-592A polymo-rphism is associated with the increased risk of CHD and may help to identify individuals at risk in the Chinese population.

关 键 词：冠状动脉疾病 白细胞介素-10 单核苷酸多态 疾病遗传易感性 

分 类 号：R541.4[医药卫生—心血管疾病]