新型缩氨基硫脲化合物的合成及其抗癌活性的研究  

SYNTHESIS AND PRELIMINARY STUDY ON A NEW CLASS ANTI TUMOR AGENTS—CETYTHIOPHENE THIOSEMICARBAZONE

作　　者：周守明[1] 金昱泰[1] 

机构地区：[1]北京师范大学化学系,北京100875

出　　处：《核化学与放射化学》1999年第4期233-238,共6页Journal of Nuclear and Radiochemistry

摘　　要：合成了6种2乙酰噻吩缩氨基硫脲,其中5种为首次合成的新物质。用红外、质谱和元素分析等方法对合成的6种化合物进行了指认。化合物的体外抗癌活性表明,它们对3种癌细胞均有一定的抑制作用。用111In标记的6种化合物的动物试验表明,放射性标记物随血液循环没有明显的定向浓集。能否为体内肿瘤细胞所摄取,有待进一步研究。Six 2 acetylthiophene TSC have been synthesized and characterized by IR,MC and elemental analysis.Five of them are the first prepared compounds.The anti tumor activities of them have been investigated. The results show that they have high inhibition to all three carcinoma cells (KB cell,HCT 8 cell and Bel 7402 cell). These ligands are labeled with 111 In.The biodistributions of six 111 In ligand complexes in mice are determined.The results show that concentrating of 111 In ligand complexes in blood is not apparent.Further study is needed to see the uptake of 111 In ligand complexes by carinoma cells.

关 键 词：2-乙酰噻吩缩氨基硫脲 抗癌活性 抗肿瘤药物 合成 铟111标记物 

分 类 号：R817.9[医药卫生—影像医学与核医学] R730.55[医药卫生—放射医学]