Behcet病患者血清TNF-α和IFN-γ及MCP-1水平的研究  

Research on the serum levels of TNF-α,IFN-γ and MCP-1 in patients with Behcet's disease

作　　者：袁永刚[1,2] 梁纳[1,2] 马胜生[1,2] 郑东健[1,2] 

机构地区：[1]暨南大学医学院第四附属医院眼科 [2]广州市红十字会医院,中国广东省广州市510220

出　　处：《国际眼科杂志》2014年第4期780-781,共2页International Eye Science

基　　金：广州市中医药科技项目(No.20132A011014)~~

摘　　要：目的:探讨Behcet病(Behcet's disease,BD)患者血清TNF-α、IFN-γ、MCP-1的水平。方法:BD患者25例,对照组为健康志愿献血员30例,抽取血清检测TNF-α、IFN-γ、MCP-1等指标。结果:BD活动期患者TNF-α、IFN-γ、MCP-1均高于健康对照组,差异有统计学意义。结论:BD活动期患者TNF-α、IFN-γ、MCP-1异常升高,可能与BD的发病机制有关。AIM：To study the serum levels of TNF-α, IFN-γand MCP-1 in patients with Behcet＇s disease （ BD） . METHOS：Twenty-five patients with BD as study group and 30 normal volunteers as control group were inclued in the study.Serum levels of TNF-α, IFN-γand MCP-1 were measured. RESULTS：Serum levels of TNF-α, IFN-γand MCP-1 were significant higher in active BD patients than in normal controls. CONCLUSION：Our results suggest that serum levels of TNF-α, IFN-γand MCP-1 abnormally increased in active BD paiteins.The higher expression may play a role in the pathogenesis of BD.

关 键 词：BEHCET病 细胞因子 TNF-Α IFN-Γ MCP-1 

分 类 号：R771.3[医药卫生—眼科] R593[医药卫生—临床医学]