E-cadherin,γ-catenin的表达与大肠癌侵袭转移的关系  

Relationship between the Expression of E-cad and γ-cat and the Invasion,Metastasis of Colorectal Carcinoma

作　　者：刘丽荣[1] 董国强[2] 李登欣[3] 孙华聪 

机构地区：[1]潍坊医学院内科学教研室,山东潍坊261053 [2]潍坊市人民医院放射科 [3]潍坊市人民医院消化内科

出　　处：《潍坊医学院学报》2014年第1期48-50,共3页Acta Academiae Medicinae Weifang

摘　　要：目的研究E-钙黏附蛋白(E-cad)和γ-连环蛋白(γ-cat)在大肠癌组织中的表达与大肠癌侵袭转移的关系。方法应用免疫组织化学二步法检测52例大肠癌组织及20例癌旁正常组织中E-cad和γ-cat的表达。结果 大肠癌组织中E-cad和γ-cat的阳性表达率均显著低于癌旁正常组织(P<0.05)。E-cad的表达与大肠癌的分化程度、临床分期、淋巴结转移、浸润深度及是否有远处器官转移密切相关(P<0.05),γ-cat的表达与大肠癌的分化程度、淋巴结转移及远处转移密切相关。大肠癌组织中E-cad和γ-cat两者的表达呈正相关(P<0.05)。结论 E-cad,γ-cat的表达在大肠癌浸润及侵袭转移的过程中起着重要作用,检测两者的表达对大肠癌的诊断、治疗及判断预后有着重要的临床意义。Objective To study the expression of E-cadherin （ E-cad ） and γ-catenin（γ-cat） in human colo- rectal carcinoma, and the relationship of their expression with the invasion and metastasis of human colorectal carcinoma. Methods The PV Immunohistochemistry method was used to detect the expression of E-cad and γ-cat in 52 cases of colorectal carcinoma and 20 cases of adjacent normal colorectal tissue. Results The expression of E-cad and γ-cat in colorectal carcinoma was significantly lower than that in adjacent normal tissue （ P 〈 0.05 ）. The expression of E-cad was closely related with the differentiatial degree, clinical stage, lymphoid metastases, depth of tumor invasion and distant or- gan metastasis of colorectal carcinoma,and the expression of γ-cat was no significant correlation in depth of tumor inva- sion. The expression of E-cad and γ-cat in colorectal cancer was positively correlated （ P 〈 O. 05 ）. Conclusion The ex- pression of E-cad and γ-cat plays an important role in progression, invasion and metastasis of colorectal carcinoma, and the detection of them has important clinical significance for diagnosis, treatment and prognosis of colorectal carcinoma.

关 键 词：大肠肿瘤 E-钙粘附蛋白 叫 连环蛋白 

分 类 号：R735.34[医药卫生—肿瘤]