P63蛋白在宣威与非宣威地区非小细胞肺癌表达的对比研究  

Expression of P63 Protein in Non-Small-Cell Lung Cancer between Xuanwei and Non-Xuanwei Region

作　　者：刘君[1,2] 李高峰[3,4] 陈楠[3,4] 彭俊[1,2] 陈新隆[1,2] 王平[1,2] 毛新[1,2] 彭浩[1,2] 张勇[3,4] 向旭东[3,4] 宁显谷[1,2] 

机构地区：[1]云南省第一人民医院 [2]昆明理工大学附属昆华医院胸心血管外科,650032 [3]昆明医学院第三附属医院 [4]云南省肿瘤医院胸外科,650118

出　　处：《医学研究杂志》2014年第3期62-65,共4页Journal of Medical Research

摘　　要：目的研究宣威与非宣威地区非小细胞肺癌P63蛋白的表达,探讨其与生物学行为的关系。方法免疫组织化学法。结果 P63蛋白在肺鳞癌组织中高表达;非小细胞肺癌中,P63蛋白的表达与患者的TNM分期、组织分化程度及淋巴结转移情况有关,与患者性别无关;P63蛋白在非小细胞肺癌中在相同病理类型、分期、组织分化、淋巴结转移情况及相同性别的阳性表达率,宣威组与非宣威组比较,差异无统计学意义。结论 P63蛋白的表达在宣威并无地区特异性,并不是宣威肺癌高发的原因。Objective Study the expression of P63 protein in the non - small - cell lung cancer（NSCLC） tissues between Xuanwei and Non - Xuanwei region, and to explore the relationship between it and the biological behavior. Methods Immunohistochemical meth- od. Results It was indicated that the expression of P63 in lung squamous cell carcinoma was extraordinarily higher. P63 was related with the TNM staging system, tissue differentiation degree and lymph node metastasis, but it was not related with sexuality. Compared Xuanwei group with the Non - Xuanwei group, the positive expression rate of P63 in non - small - cell lung cancer with the same pathological types, staging, tissue differentiation degree, lymph node metastasis and sexuality, had no statistically significant difference. Conclusion It indicated that the expression of P63 has no region - specificity in Xuanwei. It is not the reason why it has high incidence of lung cancer in Xuanwei region.

关 键 词：非小细胞肺癌P63蛋白 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤]