IL-23R rs17375018单核苷酸多态性与广西肝癌人群的相关性  

The single nucleotide polymorphism of the IL-23R gene rs17375018 is associated with hepatocellular carcinoma in Guangxi

作　　者：覃彦平 秦雪[2] 曹昭[2] 覃锦耀[2] 林观凤 吴君荣[2] 韦桂飞 潘兴益 

机构地区：[1]广西柳州市红十字会医院检验科,545001 [2]广西医科大学第一附属医院检验科,南宁530021 [3]广西柳州市红十字会医院放射科,545001 [4]广西柳州市肿瘤医院检验科,545001 [5]广西柳州市中医院检验科,545001

出　　处：《广东医学》2014年第5期674-676,共3页Guangdong Medical Journal

基　　金：广西壮族自治区卫生厅自筹经费科研课题(编号:Z2012548)

摘　　要：目的探讨IL-23R基因单核苷酸多态性与广西肝癌人群的关系。方法采用聚合酶链式反应-限制性片段长度多态性方法对270例肝癌患者和251例对照者的IL-23R rs17375018位点进行基因分型，分析其基因型、等位基因频率与肝癌的关系。结果IL-23R rs17375018位点G等位基因频率在肝癌组与对照组中的分布差异有统计学意义（OR=1．362，95％C／：1．002—1．851，P=0．049）。结论1L-23R rs17375018位点的G等位基因可能与广西肝癌人群发病相关。Objective To investigate the association between the polymorphism of IL -23R gene rs17375018 loci and hepatocellular carcinoma （HCC） in Guangxi. Methods The rs17375018 loci was analyzed by restriction fragment length poly （ PCR - RFLP） in 270 patients with HCC and 251 healthy individuals. Results There was significant dif-ferent distribution of the frequency of G alleles of IL-23R gene rs17375018 in Guangxi between HCC patients and nor-mal controls （P 〈 0.05）. Conclusion The rs17375018 of IL - 23R gene is associated with susceptibility HCC in Gaangxi.

关 键 词：白细胞介素-23R 单核苷酸多态性 聚合酶链式反应-限制性片段长度多态性 肝癌 

分 类 号：R394[医药卫生—医学遗传学]