牙源性角化囊性瘤开窗减压前后骨桥蛋白及CD44v6的表达及意义  

Expression of Osteopontin and CD44v6 and their significance in keratocystic odontogenic tumor before and after decompression

作　　者：朱江[1] 武和明[1] 王婧[1] 丁旭[1] 李怀奇[1] 邢树忠[1] 吴煜农[1] 

机构地区：[1]南京医科大学口腔医学研究所.附属口腔医院口腔颌面外科,江苏南京210029

出　　处：《口腔生物医学》2014年第1期11-14,共4页Oral Biomedicine

基　　金：江苏高校优势学科建设工程资助项目(2011-137)

摘　　要：目的:观察骨桥蛋白(osteopontin,OPN)及细胞粘附分子CD44v6在牙源性角化囊性瘤(keratocystic odontogenic tumor,KCOT)中开窗减压前后表达水平的变化。方法:收集16例经病理证实的KCOT患者开窗减压前后的病理标本,应用免疫组织化学染色法检测OPN及CD44v6的表达,并进行统计分析。结果:开窗减压前,OPN及CD44v6在KCOT中均呈高表达。减压后,16例患者OPN均呈阴性表达,统计学分析其表达在开窗后显著下降(P<0.05);CD44v6在开窗减压后标本中,10例(63%)表达下降,5例(31%)表达未发生变化,1例(6%)表达升高,统计学分析其表达在开窗后显著下降(P<0.05)。结论:OPN及CD44v6在KCOT中呈高表达,开窗减压后二者的表达水平明显降低,这可能是开窗减压术治疗KCOT的部分机制。Objective：To investigate the expression of osteopontin （OPN） and CD44v6 and their significance in keratocystic odonto-genic tumor （ KCOT） before and after decompression .Methods：All 16 pairs of paraffin-embedded tissue specimens of KCOT before and after decompression were collected and then used for immunohistochemical detection of OPN and CD 44v6.The results were statistically analyzed.Results：The expression of OPN in KCOT was down-regulated after decompression （P＆lt;0.05）.And CD44v6 expression in post-operative KCOT epithelium was significantly less than that in preoperative KCOT epithelium （P＆lt;0.05）.Conclusions：The local aggres-sive behavior of KCOT epithelium after decompression was decreased , which may be part of the mechanisms of decompression therapy .

关 键 词：牙源性角化囊性瘤 开窗减压术 骨桥蛋白 CD44V6 免疫组织化学 CD44V6 

分 类 号：R739.82[医药卫生—肿瘤]