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作 者:许金榜[1] 林丹玫[1] 林巧燕[1] 黄海龙[1] 刘超斌[1] 姜隽楹[1] 蔡远珺[1]
机构地区:[1]福建医科大学教学医院福建省妇幼保健院,福建福州350001
出 处:《中国中医药信息杂志》2014年第4期26-30,共5页Chinese Journal of Information on Traditional Chinese Medicine
基 金:福建省科技计划重点项目(2011Y0010)
摘 要:目的:观察芍药止痛合剂治疗Ⅲ~Ⅳ期子宫内膜异位症(EMs)的临床疗效,并探讨其作用机理。方法将95例Ⅲ~Ⅳ期EMs保守性手术术后患者随机分为中药组(31例)、促性腺激素释放激素激动剂(GnRHa)组(31例)和期待组(33例)。中药组口服芍药止痛合剂,GnRHa组注射醋酸曲普瑞林,期待组不作任何治疗。比较3组治疗前后血清癌抗原125(CA125)、肿瘤坏死因子-α(TNF-α)和血管内皮生长因子(VEGF)水平,疼痛程度和SF-36生存质量评分,并观察临床总有效率、妊娠和复发情况。结果治疗后3组CA125、TNF-α及VEGF水平,疼痛程度评分均较治疗前显著下降,SF-36生存质量评分显著升高,差异有统计学意义(P<0.05)。中药组与GnRHa组CA125、TNF-α、VEGF水平及疼痛程度评分下降的速度和幅度均显著高于期待组(P<0.05)。中药组总有效率为83.9%(26/31),GnRHa组为87.1%(27/31),期待组为60.6%(20/33),中药组、GnRHa组均优于期待组(P<0.05)。中药组、GnRHa组与期待组比较,妊娠率较高、复发率较低,但差异无统计学意义(P>0.05)。结论芍药止痛合剂能有效抑制异位子宫内膜生长,从而有效治疗EMs。Objective To study the effect of Shaoyaozhitong Mixture on stageⅢ-Ⅳendometriosis, and explore its mechanism. Methods Ninty-five cases of stageⅢ-Ⅳ endometriosis were randomly divided into three groups. The traditional Chinese medicine (TCM) group (31 cases) was treated with Shaoyaozhitong Mixture, the GnRHa group (31 cases) was treated with Triptorelin Acetate for Injection, while the expectant group (33 cases) received no medications. The changes of CA125, TNF-α and VEGF levels, visual pain score and SF-36 score, total effective rate, pregnancy and recurrence were compared. Results There were significant increases in CA125, TNF-α and VEGF levels, visual analogue pain score and SF-36 score in all the three groups after treatment (P〈0.05). The decline of CA125, TNF-αand VEGF levels and visual analogue pain score in TCM group and GnRHa group was significantly faster and greater than that of the expectant group (P〈0.05). The total effective rates of TCM group was 83.9%(26/31), GnRHa group was 87.1%(27/31), and expectant group was 60.6%(20/33), TCM group and GnRHa group were superior to the expectant group, respectively (P〈0.05). The pregnancy rate was higher and recurrence rate was lower in TCM group and GnRHa group than that of expectant group, but there was no statistical difference (P>0.05). Conclusion Shaoyaozhitong Mixture is effective in treating endometriosis by inhibiting the growth of ectopic endometrium.
关 键 词:子宫内膜异位症 芍药止痛合剂 促性腺激素释放激素激动剂 中医药疗法 临床疗效
分 类 号:R271.91[医药卫生—中西医结合]
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