肺癌患者血管内皮生长因子及其受体表达与FDG摄取的关系  

The relationship between the expression level of VEGF and VEGFR with the uptake degree of FDG in patients with lung cancer

作　　者：黄晓红[1] 游金辉[1] 

机构地区：[1]川北医学院附属医院核医学科,四川南充637000

出　　处：《中华临床医师杂志（电子版）》2014年第1期124-128,共5页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：肺癌是恶性肿瘤致死的首位死因,局部复发及转移是其主要原因。血管内皮因子具有刺激新生血管的作用,与肺癌肿瘤血管的生成及转移有关。近年来,PET在肺癌的诊断、分期、判断复发及疗效等方面有独到的作用。本文旨在简要综述血管内皮生长因子(VEGF)及其受体(VEGFR)的生物学行为以及VEGF结合PET检查在肺癌诊治方面的临床价值,以期提高肺癌的临床诊治水平。Lung cancer is the leading cause of death by cancer, and local recurrence and metastasis are the most important factors. The vascular endothelial growth factor （VEGF） can promote angiogenesis,which is positive related to tumor angiogenesis and metastasis. In recent years, positron emission tomography （PET） plays an important role in diagnosis, staging, recurrence and prognosis of lung cancer. This paper briefly reviewed the biological behaviors of VEGF and VEGFR, and the clinical value of VEGF combines with PET imaging for lung cancer. It is expected to promote the diagnosis and therapy of lung cancer to further level.

关 键 词：肺肿瘤 血管内皮生长因子A 受体 血管内皮生长因子 脱氧葡萄糖F18 

分 类 号：R734.2[医药卫生—肿瘤]