口服乳果糖治疗急性及亚急性肝衰竭的疗效观察与机制探讨  

Clinical Effect and the Mechanism of Oral Lactulose on Acute and Sub-acute Hepatic Failures

作　　者：刘刚[1] 江宇[1] 陈迎晓[2] 

机构地区：[1]重庆医科大学附属大学城医院,重庆401331 [2]温州医学院附属第一医院感染科,浙江温州325000

出　　处：《保健医学研究与实践》2014年第2期34-36,共3页Health Medicine Research and Practice

摘　　要：目的观察乳果糖治疗急性及亚急性肝衰竭的效果。同时探讨内源性氢气作为口服乳果糖治疗急性及亚急性肝衰竭的可能机制。方法将54例急性及亚急性肝衰竭患者分为对照组(20例)和乳果糖治疗组(34例),对照组给予常规内科治疗,乳果糖治疗组在内科治疗的基础上给予口服乳果糖8周的治疗。结果乳果糖组发生自发性腹膜炎2例,对照组14例,差异有统计学意义(P<0.05)。与对照组比较,乳果糖组患者血清总胆红素(TBIL)及血氨水平较低,差异有统计学意义(P<0.05)。乳果糖组患者凝血酶原活动度升至40%以上的时间要比对照组短,差异有统计学意义(P<0.05)。结论长期应用乳果糖干预治疗急性及亚急性肝衰竭患者可明显改善肝功能、降低血氨,其机制可能为乳果糖在肠道内产生内源性氢气有关。Objective To observe the effects of oral lactulose on the treatment of acute and sub-acute hepatic failures and to discuss the possible mechanism of endogenous hydrogen as oral lactulose to treat acute and sub- acute hepatic failures. Method 54 cases of patients with acute and sub acute hepatic failures were divided into a control group （20 cases） and a lactulose treatment group （34 cases）. The control group was received conven- tional medical treatment and the treatment group was given conventional medical treatment and 8-week treat ment of oral lactulose. Results There were two cases of spontaneous bacterial peritonitis in the treatment group and 14 cases in the control group, and the difference was statistically significant （P^0.05）. Comparing with the control group, the levels of serum total bilirubin （TBIL） and blood ammonia were higher in the treat- ment group and the differences were statistically significant （P〈0.05）. The time for prothrombin activity to rise to over 40% in patients of the treatment group was shorter than that of the control group and the differ- ence was statistically significant （P〈0.05）. Conclusion The long-term use of laetulose to treat acute and sub- acute hepatic failures can significantly improve liver function and lower blood ammonia in patients. The possi- ble mechnaieam is generating endogenous hydrogen.

关 键 词：乳果糖 急性肝衰竭 氢气 

分 类 号：R575.3[医药卫生—消化系统]