中晚期鼻咽癌适形放疗临床研究  

Late-Course Conformal Radiotherapy for Treatment of Advanced Nasopharyngeal Carcinoma

作　　者：张明[1] 袁克华 杨胜刚[1] 

机构地区：[1]云南省肿瘤医院肿瘤放疗中心,云南昆明650118 [2]昆明市延安医院,云南昆明650118

出　　处：《亚太传统医药》2014年第7期90-92,共3页Asia-Pacific Traditional Medicine

基　　金：云南省教育厅科学研究基金项目(03y482c)

摘　　要：目的:本研究为前瞻性研究,对鼻咽癌常规放射治疗与常规放疗加后程三维适形放射治疗进行比较,比较两者疗效、晚期并发症的差异。方法:45例常规放疗加后程三维适形放射治疗患者(治疗组)采用多个共面或非共面野等中心三维适形治疗。47例常规放射治疗患者(对照组)采用面颈联合野等常规治疗。结果:三维适形放疗组5年肿瘤局控率(TCP)为88.8%(40/45),常规放疗组5年肿瘤局控率(TCP)为91.4%(43/47);三维适形放疗组5年生存率71.1%(32/45);常规放疗组5年生存率74.4%(35/47),两组之间总有效率无明显差异(P>0.05)。晚期反应如涎腺功能、颞颌关节功能,后程三维适形放疗好于对照组,两组比较有显著差异(P<0.05)。结论:采用常规放疗加后程三维适形放射治疗在保证局控率同时,可有效保护敏感器官,减轻放疗不良反应,提高患者生活质量。Objective：The response to radiotherapy and its chronic side-effects compared respective by prospective study in NPC pa tients treated with late-course conformal radiotherapy （CRT）or conventional radiotherapy. Methods：Thirty-one NPC patients trea ted with late-course CRT featured isocenter irradiation in irregular fields by VARIAN2000 linear accelerator, as well as, thirty NPC patients treated with conventional radiotherapy. Results： The late-course CRT group had Five-year survival rate and 5-year tumor local control rate （TCP） that was no significant difference to control group. But significant difference was found between two groups in terms of chronic side-effects such as radiation-induced xerostomia and temporomandibular joint lesion （P% 0.05）. Conclusion： Better protection of sensitive organs, slighter radiation-induced injuries, and higher quality of life can be gained in late course CRT compare with conventional radiotherapy.

关 键 词：鼻咽癌 适形放疗 常规放疗 

分 类 号：R739.6[医药卫生—肿瘤]