帕金森病患者生物运动感知能力研究  被引量:5

Biological motion perception in patients with Parkinson's disease

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作  者:操瑞花 叶星[1] 田仰华[1] 胡盼盼[1] 陈先文[1] 汪凯[1] 

机构地区:[1]安徽医科大学第一附属医院神经内科,合肥230022

出  处:《中华行为医学与脑科学杂志》2014年第3期193-195,共3页Chinese Journal of Behavioral Medicine and Brain Science

基  金:国家自然科学基金项目(81100806,31300925,91232717)

摘  要:目的 探讨帕金森病(Parkinson's disease,PD)患者生物运动感知能力.方法 采用时距辨别任务,对45例原发性PD患者和45例正常对照组进行生物运动感知能力测试.结果 正常对照组的主观相等点(point of subjective equality,PSE)为负值(-0.27±0.17),与检验值“0”相比差异有统计学意义(t=10.96,P<0.01).PD患者组的PSE(-0.14±0.30)较正常对照组的PSE值明显减小,差异有统计学意义(t=2.63,P=0.01).PD早期组(H-Y 1-2级)的PSE值(-0.24±0.14)与正常对照组的PSE值之间差异无统计学意义(t=0.84,P=0.405),而PD晚期组(H-Y 3-4级)的PSE(0.02±0.39)负值基本消失,与正常对照组的PSE值之间差异有统计学意义(t=4.07,P=0.008).结论 PD患者存在生物运动感知障碍,且与病情的严重程度相关.Objective To explore the biological motion perception in Parkinson's disease (PD). Meth- ods 45 individuals with idiopathic PD were compared with 45 matched healthy controls (HCs) using a duration discrimination task. Results The point of subjective equality(PSE) was negative value (-0.27±0.17) for health controls (HCs) , and there was significant difference compared with "PSE = 0" by one sample t test ( t= 10.96, P〈 0.01 ) .Compared with HCs,the PSE for PD patients (-0.14±0.30) significantly decreased ( t= 2.63, P= 0.01 ). When further dividing PD into early stages (stage 1-2) and late stages (stage 3-4), significant difference was found between late-stage PD patients(0.02±0.39)and HCs ( t= 4.07, P= 0.008) ,but not between early-stage PD patients(-0.24±0.14)and HCs( t=0.84, P=0.405). Conclusion There is biological motion perception disorder in PD patients and it is related to the severity of PD.

关 键 词:帕金森病 生物运动 认知 镜像神经元 

分 类 号:R742.5[医药卫生—神经病学与精神病学]

 

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