针刺减轻盐酸帕罗西汀治疗轻中度抑郁症副作用及改善患者生存质量的研究  

Study on alleviating side effect of paroxetine and improving quality of life using acupuncture in treatment of mild or moderate depression

作　　者：王思涵[1] 王远征[2] 马学红[3] 郭卓[1] 杨昕婧[1] 张文悦[1] 郭天蔚[1] 图娅[1] 

机构地区：[1]北京中医药大学针灸推拿学院,北京100029 [2]北京大学第一医院,北京100029 [3]北京中医药大学东方医院,北京100029

出　　处：《中华行为医学与脑科学杂志》2014年第3期211-214,共4页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家＂十一五＂科技支撑计划项目（No.2006BAI12B05-2）;首都十大危险疾病科技成果推广项目（Z121100005512024）

摘　　要：目的 研究针刺结合盐酸帕罗西汀对轻、中度抑郁症药物副作用及患者生存质量的影响.方法 72例轻、中度抑郁症患者随机分为A组（电针＋盐酸帕罗西汀组）23例；B组（手针＋盐酸帕罗西汀组）32例；C组（盐酸帕罗西汀对照组）17例,疗程6周,疗后4周进行随访.观察治疗前后汉密尔顿抑郁量表（hamilton depression scale,HAMD）、抗抑郁药副反应量表（rating scale for side effects,SERS）及生存质量简表（the world health organization quality of life,WHOQOL-BREF）的总评分变化情况.结果 三组基线均衡可比,HAMD评分显示A组、B组的总有效率和治疗各时段的评分均显著优于C组,A、C两组疗效差异有统计学意义（Z=3.2242,P＜0.05）,B、C两组疗效差异有统计学意义（Z=2.6224,P＜0.05）,而A、B两组之间差异无统计学意义（Z=-0.5751,P＞0.05）.SERS评分显示A组、B组在治疗后各时段的评分显著优于C组,分别为2周（F=5.48,P＜0.05）、4周（F=7.70,P＜0.05）、6周（F=7.73,P＜0.05）,而A、B两组间差异无统计学意义（P＞D.05）.WHOQOL-BREF评分显示,A组和B组疗后在5个领域的评分显著优于C组,分别为总的生存质量主观感受（F=4.19,P＜0.05）、总健康状况主观感受（F=4.49,P＜0.05）、生理领域（F=12.46,P＜0.05）、心理领域（F=10.52,P＜0.05）及环境领域（F=5.36,P＜0.05）,而A、B两组间差异无统计学意义（P＞0.05）.结论 针刺可减轻盐酸帕罗西汀治疗轻中度抑郁症副作用并改善患者生存质量.Objective To study the effect of acupuncture on alleviating side effect of paroxetine and im- proving quality of life in treating mild or moderate depression. Methods A randomized controlled clinical trial was performed. Inpatients and outpatients with depression （ n = 72 ） were randomly divided into electro-acupuncture （EA） and paroxetine group （group A, n= 23） , manual acupuncture and paroxetine group （group B, n= 32 ） and paroxetine alone group （group C, n-- 17）. Outcome was assessed with Hamilton depression scale（HAMD） at base- line and weeks 1,2,4,and 6. Side effects were assessed with rating scale for side effects（SERS） at baseline and weeks 2,4,and 6.The world health organization quality of life（WHOQOL-BREF） scale on quality of life was given at baseline and week 6. Results There were no differences among the three groups at baseline （P〉0.05）. Accord- ing to the HAMD scores,significant difference was seen between group A and C （Z = 3.2242, P〈0.05） , and also between group B and C（ Z = 2.6224, P〈0.05）. No significant difference was found between the two acupuncture groups （P〉0.05）. SERS scores in the acupuncture groups were significantly lower than those for paroxetine alone at weeks 2（F=5.48, P〈0.05）,week 4（F=7.70, P〈0.05）,and week 6 （F=7.73, P〈0.05）. WHOQOL-BREF scores were significantly higher in the two acupuncture groups than those in the paroxetine only group in five periods, which were total subjective feelings regarding quality of life （F= 4.19, P〈0.05）, health sensation （F= 4.49, P〈 0.05） ,physical condition（F= 12.46, P〈0.05 ） , psychology condition （F= 10.52, P〈0.05 ） and circumstances （F= 5.36, P〈0.05）. Conclusion Acupuncture can alleviate side effect of paroxetine and improve quality of life in treating mild or moderate depression.

关 键 词：抑郁症 针刺治疗 副作用 生存质量 

分 类 号：R749.4[医药卫生—神经病学与精神病学]