血清炎症因子对首发抑郁患者双侧海马区细胞代谢影响的磁共振波谱研究  

Effect of inflammatory cytokines of blood serum on cell metabolism of bilateral hippocampus in the first episode depression： a magnetic resonance spectroscopy study

作　　者：朱彦[1] 王冬青[1] 李月峰[1] 朱海涛[1] 殷瑞根[1] 赵亮[1] 赵天[1] 

机构地区：[1]江苏大学附属医院影像科,镇江212001

出　　处：《中华行为医学与脑科学杂志》2014年第3期231-233,共3页Chinese Journal of Behavioral Medicine and Brain Science

摘　　要：目的 探究血清炎症因子在抑郁症发病过程中对双侧海马区细胞代谢所产生的影响.方法 利用氢质子磁共振波谱技术（1 H-MRS）技术分别检测20例首发抑郁症患者及20例健康志愿者的双侧海马的各代谢指标,并采集静脉血、检测各组受试者血清中白介素6（IL-6）、白介素2（IL-2）及白介素10（IL-10）的水平,最后将波谱检测结果与血清炎症因子水平进行相关性分析.结果 相对于正常组,首发抑郁组患者左侧海马的Glx/Cr及NAA/Cr显示下降[Glx/Cr：（0.82±0.48）,t=2.69,P＜0.05；NAA/Cr：（1.12±0.44）,t=2.81,P＜0.05],而Cho/Cr显示升高[（2.49±0.78）,f=2.36,P＜0.05],MI/Cr变化差异无统计学意义；右侧海马仅仅出现Glx/Cr的下降[（0.84±0.47）,t=2.43,P＜0.05],其余指标变化均差异无统计学意义.相对于正常组,首发抑郁组患者外周血血清中IL-6及IL-2水平升高[IL-6：（12.47±3.19） ng/L,t=4.53,P＜0.05；IL-2：（29.44±5.72） ng/L,t=2.44,P＜0.05]；IL-10水平变化差异无统计学意义.双侧海马的Glx/ Cr 水平与IL-6、IL-2水平呈明显负相关[左侧：（IL-6：r=-0.555,P＜0.05; IL-2：r=-0.624,P＜0.05）；右侧：（IL-6：r=-0.575,P＜0.05; IL-2：r=-0.523,P＜0.05）]；左侧海马的NAA/Cr水平与IL-6、IL-2水平亦呈明显负相关（IL-6：r=-0.582,P＜0.05; IL-2：r=-0.607,P＜0.05）,左侧海马的Cho/Cr水平IL-6、IL-2水平成明显正相关（IL-6：r=0.601,P＜0.05；IL-2：r=0.552,P＜0.05）.结论 海马区细胞谷氨酸系统异常是首发抑郁症的重要表现及潜在始发环节,血清炎症因子水平的变化可能是产生这种异常的一个重要因素.Objective To explore the cell metabolism of the bilateral hippocampus effected by the inflam- matory fac, tor of blood sermn in the development of the depression. Methods Using Proton magnetic resonance spectroscopy J H-MRS technology to detect multiple metabolic indices of the bilateral hippocampus of 20 first epi- sode depression patients and 20 healthy persons,and detecting the levels of IL-6,IL-2, IL-10 in blood serum were detected. Finally the correlation between them was analyzed. Results Compared with the healthy group, the values of Glx/ Cr and NAA/ Cr were reduced in left hippocampus （Glx/Cr： （0.82±0.48）, t= 2.69, P〈0.05;NAA/Cr： （1.12±0.44） , t= 2.81, P〈0.05）and the value of Cho/ Cr was increased in left hippocampus （ （2.49±0.78）, t= 2.36, P〈0.05） ,but only the value of Glx/ Cr were reduced in right hippocampus （（ 0.84±0.47）, t= 2.43, P〈 0.05） ,and the other metabolic indices changed unobvious.The depressive group bad the significantly higher levels of IL-6,1L-2 in blood serum （ 1L-6 ： （ 12.47± 3.19） ng/L, t= 4.53, P〈0.05 ; IL-2 ： （ 29.44± 5.72） ng/L, t= 2.44, P〈 0.05 ） ,but no significant difference was found in the IL-10 level in blood serum. The Glx/ Cr of bilateral hippo- campus level was negatively correlated to the IL-6 and IL-2 level in blood serum（ left：（ IL-6： r=-0.555, P〈0.05; IL-2： r=-0.624, P〈0.05） ;right：（IL-6： r=-0.575, P〈0.05; IL-2： r=-0.523, P〈0.05） ）. The NAA/ Cr of left hippocampus level was negatively correlated to the IL-6 and IL-2 level in blood serum（ IL-6： r=-0.582, P〈0.05; IL-2： r=-0.607, P〈0.05）. The Cho/Cr of left hippoeampus level was negatively correlated to the IL-6 and IL-2 level in blood serum（ IL-6： r=0.601, /）〈0.05; IL-2： r= 0.552, P〈0.05）. Conclusion The abnormal of glutamic acid system in bilateral hippocampus maybe the important performance and the potential originating link,the chan- ges of the inflammatory cytokines level maybe the factor of the

关 键 词：炎症因子 磁共振波谱学 首发抑郁症 海马 

分 类 号：R749.4[医药卫生—神经病学与精神病学]