抑郁症患者静息态功能磁共振成像与抑郁严重程度相关性研究  

Relationship between Resting- state Functional Magnetic Resonance Imaging and the Disease Severity in Patients with Depressive Disorder

作　　者：闫丽娜[1] 李翠宁[2] 苏便苓[1] 张冬青[2] 刘振红[1] 

机构地区：[1]河北医科大学第二医院精神心理科,河北省石家庄市050000 [2]河北医科大学第二医院影像科,河北省石家庄市050000

出　　处：《中国全科医学》2014年第7期800-802,共3页Chinese General Practice

摘　　要：目的应用静息态功能磁共振成像(fMRI)局部一致性(ReHo)方法探讨抑郁症患者静息态脑活动特点;结合自评抑郁量表(SDS)探讨抑郁程度与静息自发脑活动相关性。方法 2012年6—12月于河北医科大学第二医院精神心理科对10例抑郁症患者(抑郁组)及10名与之相匹配的健康志愿者(对照组)进行静息态功能磁共振成像,采用ReHo方法分析数据,研究两组受试者静息态ReHo值差异,并对抑郁组SDS得分与差异脑区ReHo值行相关分析。结果抑郁组ReHo值减低脑区:右距状回,右枕中回,左楔叶,双侧额中回、眶回、前扣带回,右缘上回、中央后回;ReHo值增加脑区:左壳核、海马、海马旁回,右壳核、尾状核头、内囊前肢、海马,左顶下小叶,左额上回腹侧。SDS评分与ReHo值相关性:与左前扣带回、眶回(r=-0.87),右额中回(r=-0.82)ReHo值呈负相关,与左楔叶(r=0.82)ReHo值呈正相关。结论静息状态下抑郁症患者皮层同步一致性活动减弱,边缘系统、基底核活动增强;抑郁程度与左前扣带回、眶回、右额中回及左楔叶ReHo值相关。Objective To assess the resting-state brain activity and establish its relationship with the disease severity in patients with major depressive disorder.Methods The resting-state brain activity in 10 patients with major depressive disorder and 10 control subjects （healthy volunteers） between June and December,2012 at Department of Mental and Psychogica,the Second Hopital of Hebei Medical University was assessed by functional magnetic resonance imaging （fMRI） using the regional homogeneity （ReHo） approach.The correlation between the score of self-rating depression scale （SDS） and ReHo measurement in depressed patients was analyzed.Results Compared with control subjects,patients with depressive disorder exhibited decreased ReHo in right dentate gyrus,right middle occipital gyrus,left cuneus,bilateral middle frontal gyrus,orbital gyri,anterior cingutate gyrus,right supramarginal gyru,and postcentral gyrus.In contrast,increased ReHo was detected in left dorsal caudate putamen,hippocampus,hippocampal gyrus,right dorsal caudate putamen,head of caudate nucleus,anterior limb of internal capsule,hippocampus,left inferior parietal lobule,and left superior frontal gyrus ventral in depressed patients.The SDS score was correlated negatively with ReHo in left anterior cingutate and orbital gyri （r =-0.87） and right middle frontal gyrus（r =-0.82） but positively with left cuneus （r =0.82）.Conclusion The regional homogeneity assed by fMRI is decreased in the cortex of the brain but increased in the limbic system and basal ganglia in patients with depressive disorder.The level of activity in left anterior cingutate,middle frontal gyrus,left superior occipital gyrus and cuneu is correlated with the severity of depression.

关 键 词：抑郁症 静息态功能磁共振成像 局部一致性 抑郁自评量表 

分 类 号：R749.42[医药卫生—神经病学与精神病学]