酪蛋白激酶Iα与细胞信号通路  

Casein Kinase 1α in Cell Signalling

作　　者：韩国灿[1] 姜少杰[2] 邹飞雁[2] 

机构地区：[1]浙江大学医学院附属邵逸夫医院,杭州310016 [2]暨南大学生命科学技术学院,广州510632

出　　处：《生物技术通报》2014年第3期22-29,共8页Biotechnology Bulletin

基　　金：国家自然科学基金资助项目(30471954);中国博士后科学基金资助项目(2003034467)

摘　　要：酪蛋白激酶Ⅰα(Casein kinase 1α,CK1α)广泛分布于各类真核生物中,是CK1家族的7个成员(CK1α、β、γ1、γ2、γ3、δ和ε)之一,序列结构高度保守。在哺乳动物中,CK1α参与多种细胞生理过程,包括膜转运,细胞周期,染色体分离,细胞凋亡和细胞分化等。此外,CK1α还参与Wnt/β-Cat,Hh及NF-κB等信号通路。将CK1α在各类信号通路的具体功能作一综述,为进一步研究其在信号通路中的地位提供参考。Casein kinase 1α（CK1α）is a member of CK1 family（CK1α, β, γ1, γ2, γ3, δ, ε）, which expressed in many eukaryotes ranging from yeast to humans, and the sequence is highly conserved. Mammalian CK1α involved in diverse cellular processes including membrane trafficking, cell cycle progression, chromosome segregation, apoptosis and cellular differentiation etc. In addition, CK1α is needed in the process of Wnt/β-Cat, Hh and NF-κB signalling pathway. The detail functions of CK1α in cell signalling, and provide reference for CK1α research was summarized.

关 键 词：酪蛋白激酶Ⅰα WNT Β-CAT 信号通路 Hh信号通路 NF-ΚB信号通路 

分 类 号：Q257[生物学—细胞生物学]