血清CEA、CYFRA21-1、NSE检测在特发性肺间质纤维化患者合并肺癌中的临床意义  

The Clinical Significance of Detection of Serum CEA,CYFRA21-1 and NSE in Patients with Idiopathic Pulmonary Fibrosis Combine Lung Cancer

作　　者：赵静[1,2] 刘瑞娟[1] 

机构地区：[1]山东省医学科学院附属济宁市第一人民医院,山东济宁272100 [2]济南大学山东省医学科学院医学与生命科学学院,山东济南250022

出　　处：《医药与保健》2014年第2期6-7,共2页Medicine and Health Care

摘　　要：目的 探讨外周血血清癌胚抗原（CEA）、细胞角蛋白19片段（CYFRA21-1）、神经元特异性烯醇化酶（NSE）3种标志物对特发性肺间质纤维化（IPF）患者合并肺癌的诊断及分型意义.方法 对2012年1月至2013年8月收入院的IPF患者33例,肺癌患者38例,IPF合并肺癌患者30例,分别作为A、B、C三组,检测3组患者CEA、CYFRA21-1、NSE值.结果 ①三组之间比较,A组与B组,A组与C组,均有显著差异（P＜0.01）,B组与C组比较,无显著差异（P＞0.05）.②各组组间分别比较CEA、NSE均有显著差异（P＜0.05）,A组与B组,A组与C组比较,CYFRA21-1均有显著差异（P＜0.05）,B组与C组比较,上述指标无显著差异（P＞0.05）.③各组组内CEA、CYFRA21-1、NSE值比较,A组内,NSE ＞CYFRA21-1＞CEA,B组内,NSE＞CEA ＞CYFRA21-1,C组内,NSE＞CEA ＞CYFRA21-1.结论 血清CEA、CYFRA21-1、NSE检测对特发性肺间质纤维化患者合并肺癌的诊断具有临床价值,还可用于对其分型.Objective To explore the clinical significance of detection of carcinoembryonic antigen （CEA） and cytokeratin 19 fragment （CYFRA21 1）,neuron specific enolization enzyme （NSE） three markers in idiopathic pulmonary fibrosis patients combine lung cancer （IPF-LC）.Methods All patients in this research were admitted in January 2012 to August 2013.33 cases of patients with IPF were as group A,38 cases of patients with Lung Cancer were as group B,30 cases of patients with 1PF-LC were as group C.CEA,CYFRA21-1 and NSE of 3 groups were detected.Results （1）The comparation between group A and B showed significant difference （P〈0.01）,The comparafion between group A and C showed significant difference （P〈0.01）,but The comparation between group B and C showed non-significant difference （P〉0.05）. （2）CEA,NSE：the comparation between each group showed significant differences （all P〈0.05）, CYFRA21-1：the comparation between group A and B,A and C showed significant differences （all P〈0.05）,the comparation between group B and C showed non-significant difference （P〉0.05）.（3）The three makers comparation in each group,in group A： NSE〉CYFRA21-1〉CEA,in group B and C： NSE〉CEA 〉CYFRA21-1.Conclusion The detection of CEA,CYFRA21-1 ,NSE can be used to diagnosis the patients with IPF-PC,it can also be used for the classification.

关 键 词：癌胚抗原 细胞角蛋白19片段 神经元特异性烯醇化酶 IPF 肺癌 

分 类 号：R734.2[医药卫生—肿瘤]