新型呋喃甲酰基吡唑酮缩胺类席夫碱的合成与抑菌活性  

Synthesis and Antibacterial Activity of Novel Schiff Bases Derived from Furoylpyrazolone and Amine Compounds

作　　者：俞志刚[1] 李凤琴[1] 竹学友[1] 陈延辉[1] 李晓霞[1] 李东颖[1] 

机构地区：[1]哈尔滨理工大学化学与环境工程学院绿色化工技术黑龙江省高校重点实验室,黑龙江哈尔滨150040

出　　处：《化学试剂》2014年第4期309-312,324,共5页Chemical Reagents

基　　金：黑龙江省教育厅科学技术基金资助项目(1151-1082)

摘　　要：在非水溶剂中合成了6种标题化合物。用元素分析、IR、1HNMR和LC-MS对其结构进行了表征,同时初步考察了6个化合物的抑菌活性。表征结果显示,不同测试条件下,6个化合物可以酮式和烯醇式异构体方式共存。抑菌活性测定结果表明,6个化合物对受试的4个菌种抑菌活性程度不同,抑菌能力遵循浓度效应。Six novel Schiff bases derived from fnroylpyrazolone and amine compounds have been synthesized in the nonaque- ous solvent. The molecular structures were confirmed by ele- mental analysis, IR, i HNMR and liquid chromatography cou- pled with mass spectrometry. And the antibacterial activities of these six Sehiff bases were also investigated with Oxford cup method. The results indicate that the isomers of six com- pounds exist differently under different testing conditions. The antibacterial activity showed that all six compounds were all resistant to four different bacteria with various degrees, the va- rying trend of antibacterial performance followed the concen- tration effect.

关 键 词：呋喃甲酰基吡唑酮 席夫碱 合成 抑菌活性 

分 类 号：O614.33[理学—无机化学] O626.21[理学—化学]