AFP联合AFP-L3、GPDA和CA125在原发性肝癌诊断中的可能价值  

Co-detection of AFP,AFP-L3,GPDA and CA125 and Its Clinical Value in Diagnosis of Primary Liver Cancer

作　　者：郑飞[1] 王春晖[1] 周文平[1] 

机构地区：[1]中国人民解放军沈阳军区总医院肝胆外科,沈阳110840

出　　处：《医学综述》2014年第6期1117-1119,共3页Medical Recapitulate

基　　金：辽宁省科技攻关项目(2013225220)

摘　　要：目的 探究血清甲胎蛋白（AFP）、甲胎蛋白异质体（AFP-L3）、甘氨酰脯氨酸二肽氨基肽酶（GPDA）和糖类抗原125（CA125）联检对原发性肝癌诊断的临床价值.方法 选取中国人民解放军沈阳军区总医院2010-2012年度收治的患者和体检人群,其中65例原发性肝癌、57例乙型肝炎和60例正常体检者,测定AFP、AFP-L3、GPDA和CA125的血清水平.结果 AFP、AFP-L3、GPDA和CA125四种肿瘤标志物的血清水平以原发肝癌组最高,乙型肝炎组次之,正常对照组最低.AFP、AFP-L3、GPDA和CA125对原发性肝癌的单项检测阳性率分别为78.5％、76.9％、69.2％和70.8％;AFP联合AFP-L3的灵敏度为87.7％,AFP联合GPDA的阳性率为86.2％;AFP联合CA125的阳性率为86.2％,四项联检阳性率为92.3％,均比任一单项阳性率高（P＜0.05）.结论 联合多项肿瘤标志物的血清学检测能提高原发性肝癌诊断率.Objective To investigate the clinical value of co-detection of AlP,AFP-L3,GPDA and CA125 in diagnosing primary liver cancer.Methods Sixty-five cases of primary liver cancer,57 cases of type B hepatitis and 60 healthy individuals were recruited from the General Hospital of Shenyang Military Command during year 2010-2012,and then serum levels of AFP,AFP-L3,GPDA and CA125 were assessed.Results Serum levels of AFP,AFP-L3,GPDA and CA125 were all highest in primary liver cancer group,followed by type B hepatitis group and normal control group.The individual detection sensitivity for AFP,AFP-L3,GPDA and CA125 was 78.5%,76.9%,69.2% and 70.8% respectively.Co-detection sensitivity of AFP and AFP-L3 was 87.7%,co-detection sensitivity of AFP and GPDA was 86.2% and co-detection sensitivity of AFP and CA125 was 86.2%,all showing increase as compared to any of the individual detection sensitivity.Additionally,the co-detection sensitivity of AFP,AFP-L3,GPDA and CA125 was 92.3%,showing a significant elevation as compared to any of the individual detection sensitivity（P 〈0.05）.Conclusion Co-detection of multiple serum tumor-markers can significantly improve the diagnosis rate of primary liver cancer.

关 键 词：原发性肝癌 联检 肿瘤标志物 

分 类 号：R735.7[医药卫生—肿瘤]