艾司西酞普兰与氯丙咪嗪治疗惊恐障碍的临床对照研究  

A controlled trial of of escitalopram and clomipramine in treatment of panic disorder

作　　者：刘晓[1] 李侃虔 周文娟[1] 文萍[1] 

机构地区：[1]天水市第三人民医院,741000

出　　处：《四川精神卫生》2014年第1期57-59,共3页Sichuan Mental Health

摘　　要：目的比较艾司西酞普兰和氯丙咪嗪治疗惊恐障碍的临床疗效和安全性。方法采用随机数字表将68例惊恐障碍患者分为艾司西酞普兰组(n=34)和氯丙咪嗪组(n=34),分别给予艾司西酞普兰和氯丙咪嗪治疗,疗程均为10周,分别于治疗前及治疗后1、2、4、6、8、10周末采用惊恐相关症状量表(PASS)、汉密尔顿焦虑量表(HAMA)及副反应量表(TESS)分别评定疗效及安全性。结果治疗后,两组PASS和HAMA评分均较治疗前下降,差异有统计学意义(P均<0.01)。艾司西酞普兰组和氯丙咪嗪组有效率分别为87.5%和81.3%,差异无统计学意义(P>0.05)。艾司西酞普兰组和氯丙咪嗪组TESS评分[(2.78±1.03)vs.(4.07±2.89)],差异有统计学意义(P<0.05)。结论艾司西酞普兰治疗惊恐障碍疗效与氯丙咪嗪相当,但艾司西酞普兰组不良反应少,安全性好。Objective To evaluate the efficacy and safety of escitalopram and clomipramine in treatment of panic disorder. Methods In this study, 68 patients diagnosed with panic disorder were randomly divided into two groups within 34 patients each group. The study group were administered with escitalopram while control group treated with clomipramine, both lasted for 10 weeks. , The efficacy was evaluated by PASS and HAMA. and the safety was assessed in terms of TESS before and 1,2,4,6,8,10weeks after treatment respectively. Results The PASS scores and HAMA scores were significantly declined after treatment （ P 〈 0.01 ）. The ef- fective rates of escitalopram group and elomipramine group were 87.5% and 81.3%, the two groups showed no significant difference from X2 test （ P 〉 0.05 ）. The TESS scores of escitalopram group and clomipramine group were （ 2.78 ± 1.03 ） and （ 4.07 ± 2.89 ） , which were significant difference between two groups by t - test （P 〈 0.05）. Conclusion Escitalopram had similar curative effects with clomipramine, less adverse reactions and safer in treatment of panic disorder.

关 键 词：艾司西酞普兰 氯丙咪嗪 惊恐障碍 

分 类 号：R749[医药卫生—神经病学与精神病学]