去乙酰化酶SIRT3与肿瘤代谢  

SIRT3 and tumor metabolism

作　　者：汪晓强[1] 缪明永[1] 

机构地区：[1]第二军医大学生物化学与分子生物学教研室,上海200433

出　　处：《中华普通外科学文献（电子版）》2014年第1期53-57,共5页Chinese Archives of General Surgery(Electronic Edition)

摘　　要：SIRT3是线粒体内一种重要的去乙酰化酶,对协调线粒体内复杂的代谢反应起关键作用。在抑制肿瘤发生方面,SIRT3通过抗肿瘤代谢再编程保护正常细胞而避免向肿瘤细胞转化和肿瘤发生。SIRT3调节细胞对葡萄糖的摄取,增加细胞抗氧化能力,提高电子传递链中复合体的活性,促进细胞内NADPH的生成,控制能量产生等,从多层次和多角度实现抗肿瘤代谢再编程。这对临床肿瘤诊断和治疗有一定的理论指导,并为肿瘤治疗提供新的策略和方法。SIRT3 is an important deacetylase in the mitochondria, and plays a critical role in coordinating multiple mitochondrial metabolism. With respect to its inhibition of tumor formation, SIRT3 protects normal cells from developing into tumor cells and tumorigenesis through against the reprogramming of tumor metabolism. SIRT3 regulates cells to intake the glucose, improves the ability of defending oxidation and the activities of oxidative phosphorylation complexes, promotes NADPH production and controls the production of energy. So SIRT3 indeed resists the reprogramming of tumor metabolism by multiple mitochondrial processes. This theory that SIRT3 can inhibit the reprogramming of tumor metabolism plays a guiding role in the early detection and treatment of clinical cancer, which will provide new strategies and methods for the treatment of cancer.

关 键 词：SIRT3 肿瘤代谢再编程 线粒体 去乙酰化酶 

分 类 号：R730.5[医药卫生—肿瘤]