血清胱抑素C的水平变化与帕金森病的关系  

Preliminary relationship between serum cystatin C level and Parkinson＇s disease

作　　者：徐金敏[1] 陈静[1] 毛成洁[1] 杨亚萍[2] 刘春风[2] 

机构地区：[1]苏州大学附属第二医院神经内科,215004 [2]苏州大学附属第二医院神经内科 苏州大学神经科学研究所,215004

出　　处：《中华医学杂志》2014年第11期804-807,共4页National Medical Journal of China

基　　金：“江苏省医学领军人才与创新团队”（201115）及苏州市医学重点学科专项（201301）;苏州市科技发展计划（SZS201205）;苏州市科教兴卫青年科技项目（201013）

摘　　要：目的 研究血清胱抑素C水平变化与帕金森病患者相关临床指标及分期之间的关系.方法 收集2011年7月至2012年12月在苏州大学附属第二医院神经内科经临床确诊为帕金森病的患者115例,检测这115例帕金森病患者的血清胱抑素C,选取同时间段内在苏州大学附属第二医院体检中心体检的110名健康中老年人作为对照组,采用SPSS 17.0软件对数据进行统计分析.结果 帕金森病组血清胱抑素C平均水平为（1.06±0.20） mg/L,健康对照组为（0.96±0.16） mg/L,组间均数比较差异有统计学意义（t=6.663,P＜0.05）.斯皮尔曼等级相关分析提示血清胱抑素C水平只与年龄（r =0.381,P＜0.001）、血肌酐（r=0.267,P =0.004）之间呈正相关,与尿素、尿酸、胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白没有相关性（P＞0.05）.方差分析提示中晚期帕金森病患者的血清胱抑素C水平较高（P＜0.05）.结论 血清胱抑素C在帕金森病的进程中可能起一定作用.Objective To explore the role of serum cystatin C level in Parkinson＇s disease （PD） and evaluate the relationship between cystatin C level and clinical characteristics and different stages of PD. Methods A total of 115 PD patients and 110 healthy controls were recruited. The results of such routine laboratory tests as triglyceride, cholesterol, low-density lipoprotein （LDL）, high-density lipoprotein （HDL） , ereatinine, urea, uric acid and cystatin C were assessed from fasting blood samples at our clinical laboratory center. They were further divided into subgroups according to Hoehn ＆ Yahr （ H＆Y ） staging. Statistical analysis was performed with SPSS version 17.0 software. Results Compared to controls （0. 96 ＋ 0. 16 rag/L）, the mean serum level of cystatin C was significantly higher in PD patients （1.06 ＋ 0. 20 rag/L）. Spearman＇s correlation analyses showed a positive and significant correlation between cystatin C levels and age as well as creatinine levels. Correlation was not found between cystatin C level and triglyceride, cholesterol, LDL, HDL, urea or uric acid. ANOVA analysis showed that cystatin C had a higher level during the middle and late stages of PD than that during the early stage. Conclusion Cystatin C level may play an important role in the progression of PD.

关 键 词：血清胱抑素C 帕金森病 

分 类 号：R742.5[医药卫生—神经病学与精神病学]